Meta-analysis and review of functional neuroimaging differences underlying adolescent vulnerability to substance use

• Published in: NeuroImage (Orlando, Fla.) Vol. 209; p. 116476
• Main Authors: Tervo-Clemmens, Brenden, Quach, Alina, Calabro, Finnegan J., Foran, William, Luna, Beatriz
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2020; Elsevier Limited; Elsevier
• Subjects: Addiction; Adolescence; Adolescent; Adolescent Behavior - physiology; Adolescents; Alcoholism; Brain mapping; Child development; Children of alcoholics; Cognitive ability; Cognitive control; Corpus Striatum - diagnostic imaging; Corpus Striatum - physiopathology; Critical period; Drug use; Executive Function - physiology; fMRI; Functional magnetic resonance imaging; Functional Neuroimaging; Humans; Medical imaging; Meta-analysis; Neostriatum; Neurodevelopmental disorders; Neuroimaging; Prefrontal cortex; Psychopathology; Putamen; Reinforcement; Reward; Statistical analysis; Striatum; Substance use disorder; Substance use risk; Substance-Related Disorders - diagnostic imaging; Substance-Related Disorders - epidemiology; Substance-Related Disorders - physiopathology; Systematic review; Teenagers; Children of alcoholics; Substance use disorder; fMRI; Adolescence; Striatum; meta-Analysis; Addiction; Substance use risk; Reward; Cognitive control

Adolescence is increasingly viewed as a sensitive period in the development of substance use disorders (SUDs). Neurodevelopmental ‘dual-risk’ theories suggest adolescent vulnerability to problematic substance use is driven by an overactive reward drive mediated by the striatum, and poor cognitive co...