Covalent adduction of endogenous and food-derived quinones to a protein: its biological significance

There are many chemically reactive compounds, including quinone, in living systems and also food. Even after the ingestion of food polyphenols, quinones derived from catechol moieties could form endogenously in the body. Dopaquinone, dopamine quinone, estrogen-derived quinones, tryptamine-4,5-dione,...

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Published inJournal of Clinical Biochemistry and Nutrition Vol. 62; no. 3; pp. 213 - 220
Main Authors Kato, Yoji, Suga, Naoko
Format Journal Article
LanguageEnglish
Published Japan SOCIETY FOR FREE RADICAL RESEARCH JAPAN 2018
Japan Science and Technology Agency
the Society for Free Radical Research Japan
Subjects
biological action
Catechol
Chemical reactions
covalent modification
Dopamine
endogenous quinone
Estrogens
Food
food-derived quinone
Ingestion
Physiological effects
Polyphenols
Quinones
Serial Review
Tryptamine
Ubiquinone
catechol
endogenous quinone
covalent modification
biological action
food-derived quinone
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Summary:There are many chemically reactive compounds, including quinone, in living systems and also food. Even after the ingestion of food polyphenols, quinones derived from catechol moieties could form endogenously in the body. Dopaquinone, dopamine quinone, estrogen-derived quinones, tryptamine-4,5-dione, and ubiquinone are examples of an endogenous quinone. These indicate that quinone is ubiquitously formed or present in living systems and food. Quinones can induce a variety of hazardous effects and also could have beneficial physiological effects. This review focuses on the chemical reactivity of quinone toward a biomolecule and its biological action.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:0912-0009
1880-5086
DOI:10.3164/jcbn.18-26