Independent Elaboration of Steroid Hormone Signaling Pathways in Metazoans
Steroid hormones regulate many physiological processes in vertebrates, nematodes, and arthropods through binding to nuclear receptors (NR), a metazoan-specif ic family of ligand-activated transcription factors. The main steps controlling the diversification of this family are now well-understood. In...
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| Published in | Proceedings of the National Academy of Sciences - PNAS Vol. 106; no. 29; pp. 11913 - 11918 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
National Academy of Sciences
21.07.2009
National Acad Sciences |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0027-8424 1091-6490 1091-6490 |
| DOI | 10.1073/pnas.0812138106 |
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| Abstract | Steroid hormones regulate many physiological processes in vertebrates, nematodes, and arthropods through binding to nuclear receptors (NR), a metazoan-specif ic family of ligand-activated transcription factors. The main steps controlling the diversification of this family are now well-understood. In contrast the origin and evolution of steroid ligands remain mysterious, although this is crucial for understanding the emergence of modern endocrine systems. Using a comparative genomic approach, we analyzed complete metazoan genomes to provide a comprehensive view of the evolution of major enzymatic players implicated in steroidogenesis at the whole metazoan scale. Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages, and that steroidogenic cytochrome P450 enzymes descended from those that detoxify xenobiotics. |
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| AbstractList | Steroid hormones regulate many physiological processes in vertebrates, nematodes, and arthropods through binding to nuclear receptors (NR), a metazoan-specific family of ligand-activated transcription factors. The main steps controlling the diversification of this family are now well-understood. In contrast, the origin and evolution of steroid ligands remain mysterious, although this is crucial for understanding the emergence of modern endocrine systems. Using a comparative genomic approach, we analyzed complete metazoan genomes to provide a comprehensive view of the evolution of major enzymatic players implicated in steroidogenesis at the whole metazoan scale. Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages, and that steroidogenic cytochrome P450 enzymes descended from those that detoxify xenobiotics. Steroid hormones regulate many physiological processes in vertebrates, nematodes, and arthropods through binding to nuclear receptors (NR), a metazoan-specific family of ligand-activated transcription factors. The main steps controlling the diversification of this family are now well-understood. In contrast, the origin and evolution of steroid ligands remain mysterious, although this is crucial for understanding the emergence of modern endocrine systems. Using a comparative genomic approach, we analyzed complete metazoan genomes to provide a comprehensive view of the evolution of major enzymatic players implicated in steroidogenesis at the whole metazoan scale. Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages, and that steroidogenic cytochrome P450 enzymes descended from those that detoxify xenobiotics.Steroid hormones regulate many physiological processes in vertebrates, nematodes, and arthropods through binding to nuclear receptors (NR), a metazoan-specific family of ligand-activated transcription factors. The main steps controlling the diversification of this family are now well-understood. In contrast, the origin and evolution of steroid ligands remain mysterious, although this is crucial for understanding the emergence of modern endocrine systems. Using a comparative genomic approach, we analyzed complete metazoan genomes to provide a comprehensive view of the evolution of major enzymatic players implicated in steroidogenesis at the whole metazoan scale. Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages, and that steroidogenic cytochrome P450 enzymes descended from those that detoxify xenobiotics. Steroid hormones regulate many physiological processes in vertebrates, nematodes, and arthropods through binding to nuclear receptors (NR), a metazoan-specif ic family of ligand-activated transcription factors. The main steps controlling the diversification of this family are now well-understood. In contrast the origin and evolution of steroid ligands remain mysterious, although this is crucial for understanding the emergence of modern endocrine systems. Using a comparative genomic approach, we analyzed complete metazoan genomes to provide a comprehensive view of the evolution of major enzymatic players implicated in steroidogenesis at the whole metazoan scale. Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages, and that steroidogenic cytochrome P450 enzymes descended from those that detoxify xenobiotics. Steroid hormones regulate many physiological processes in vertebrates, nematodes, and arthropods through binding to nuclear receptors (NR), a metazoan-specific family of ligand-activated transcription factors. The main steps controlling the diversification of this family are now well-understood. In contrast, the origin and evolution of steroid ligands remain mysterious, although this is crucial for understanding the emergence of modern endocrine systems. Using a comparative genomic approach, we analyzed complete metazoan genomes to provide a comprehensive view of the evolution of major enzymatic players implicated in steroidogenesis at the whole metazoan scale. Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages, and that steroidogenic cytochrome P450 enzymes descended from those that detoxify xenobiotics. [PUBLICATION ABSTRACT] |
| Author | Markov, Gabriel V. Laudet, Vincent Tavares, Raquel Baker, Michael E. Demeneix, Barbara A. Dauphin-Villemant, Chantal Gustafsson, Jan Åke |
| Author_xml | – sequence: 1 givenname: Gabriel V. surname: Markov fullname: Markov, Gabriel V. – sequence: 2 givenname: Raquel surname: Tavares fullname: Tavares, Raquel – sequence: 3 givenname: Chantal surname: Dauphin-Villemant fullname: Dauphin-Villemant, Chantal – sequence: 4 givenname: Barbara A. surname: Demeneix fullname: Demeneix, Barbara A. – sequence: 5 givenname: Michael E. surname: Baker fullname: Baker, Michael E. – sequence: 6 givenname: Vincent surname: Laudet fullname: Laudet, Vincent – sequence: 7 givenname: Jan Åke surname: Gustafsson fullname: Gustafsson, Jan Åke |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19571007$$D View this record in MEDLINE/PubMed https://hal.inrae.fr/hal-02666864$$DView record in HAL |
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| Copyright | Copyright National Academy of Sciences Jul 21, 2009 Distributed under a Creative Commons Attribution 4.0 International License |
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| Keywords | STEROIDOGENESIS EVOLUTION GENOMIQUE NUCLEAR-RECEPTOR LIGAND |
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| Notes | SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 PMCID: PMC2715501 Author contributions: G.V.M. and V.L. designed research; G.V.M. performed research; G.V.M., R.T., and V.L. analyzed data; and G.V.M., C.D.-V., B.A.D., M.E.B., and V.L. wrote the paper. Edited by Jan-Åke Gustafsson, Karolinska Institutet, Stockholm, Sweden, and approved May 26, 2009 |
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| Snippet | Steroid hormones regulate many physiological processes in vertebrates, nematodes, and arthropods through binding to nuclear receptors (NR), a metazoan-specif... Steroid hormones regulate many physiological processes in vertebrates, nematodes, and arthropods through binding to nuclear receptors (NR), a metazoan-specific... |
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| SubjectTerms | Animals arthropods Biological Sciences Computer Science cytochrome P-450 Cytochrome P-450 Enzyme System - genetics Endocrine system Enzymes Evolution Evolution, Molecular Gene Duplication genome Genomics Hormones Hormones - metabolism Life Sciences Ligands Likelihood Functions Models, Genetic Molecules Nematoda Nematodes Nuclear receptors Oxidoreductases - genetics Phylogenetics Phylogeny Receptors Signal Transduction Species Specificity Steroid hormones steroidogenesis Steroids Steroids - metabolism transcription factors Vertebrates Vertebrates - genetics Xenobiotics |
| Title | Independent Elaboration of Steroid Hormone Signaling Pathways in Metazoans |
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