Disparity between dorsal and ventral networks in patients with obsessive-compulsive disorder: evidence revealed by graph theoretical analysis based on cortical thickness from MRI

As one of the most widely accepted neuroanatomical models on obsessive-compulsive disorder (OCD), it has been hypothesized that imbalance between an excitatory direct (ventral) pathway and an inhibitory indirect (dorsal) pathway in cortico-striato-thalamic circuit underlies the emergence of OCD. Her...

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Published inFrontiers in human neuroscience Vol. 7; p. 302
Main Authors Kim, Seung-Goo, Jung, Wi Hoon, Kim, Sung Nyun, Jang, Joon Hwan, Kwon, Jun Soo
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 03.07.2013
Frontiers Media S.A
Subjects
Alzheimer's disease
Anatomy
Attention deficit hyperactivity disorder
Brain
Brain architecture
Cortex
cortical thickness
graph theoretical analysis
Magnetic Resonance Imaging
Medical imaging
Morphology
Network efficiency
Neuroimaging
Neuroscience
Neuroses
NMR
Nuclear magnetic resonance
Obsessive compulsive disorder
Psychiatry
structural connectivity
Studies
Thalamus
South Korea
small-worldness
magnetic resonance imaging
network efficiency
cortical thickness
obsessive-compulsive disorder
structural connectivity
dorsal-ventral imbalance
graph theoretical analysis
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Summary:As one of the most widely accepted neuroanatomical models on obsessive-compulsive disorder (OCD), it has been hypothesized that imbalance between an excitatory direct (ventral) pathway and an inhibitory indirect (dorsal) pathway in cortico-striato-thalamic circuit underlies the emergence of OCD. Here we examine the structural network in drug-free patients with OCD in terms of graph theoretical measures for the first time. We used a measure called efficiency which quantifies how a node transfers information efficiently. To construct brain networks, cortical thickness was automatically estimated using T1-weighted magnetic resonance imaging. We found that the network of the OCD patients was as efficient as that of healthy controls so that the both networks were in the small-world regime. More importantly, however, disparity between the dorsal and the ventral networks in the OCD patients was found in terms of graph theoretical measures, suggesting a positive evidence to the imbalance theory on the underlying pathophysiology of OCD.
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Reviewed by: Rik Vandenberghe, Katholieke Universiteit Leuven, Belgium; Zhang Chen, University of Alberta, Canada
Edited by: Yong He, Beijing Normal University, China
ISSN:1662-5161
1662-5161
DOI:10.3389/fnhum.2013.00302