Characterization of antioxidant polyphenols from Myrciaria jaboticaba peel and their effects on glucose metabolism and antioxidant status: A pilot clinical study

• Published in: Food chemistry Vol. 211; pp. 185 - 197
• Main Authors: Plaza, Merichel, Batista, Ângela Giovana, Cazarin, Cinthia Baú Betim, Sandahl, Margareta, Turner, Charlotta, Östman, Elin, Maróstica Júnior, Mário Roberto
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 15.11.2016
• Subjects: Adult; aerosols; Aerosols - chemistry; Agricultural and Veterinary sciences; Agricultural Science, Forestry and Fisheries; Agricultural Sciences; Agriculture, Forestry and Fisheries; anthocyanins; Anthocyanins - analysis; antioxidant activity; Antioxidant capacity; antioxidants; Antioxidants - metabolism; Area Under Curve; Blood Glucose - analysis; blood serum; Chromatography, High Pressure Liquid; Cross-Over Studies; electrochemistry; ellagic acid; Ellagic Acid - analysis; Female; flavonols; Food Science; Food Science (including Product Quality); Fruit - chemistry; glucose; Glycemia; high performance liquid chromatography; HPLC-DAD-ECD-CAD; HPLC-qTOF-MS; Humans; Hydrolyzable Tannins - analysis; Insulin; Jaboticaba; Jordbruk, skogsbruk och fiske; Lantbruksvetenskap och veterinärmedicin; Lantbruksvetenskap, skogsbruk och fiske; Light; Livsmedelsvetenskap; Livsmedelsvetenskap (Här ingår: Produktkvalitet); Male; Mass Spectrometry; metabolism; Myrciaria; Myrciaria jaboticaba; Myrtaceae - chemistry; oxidative stress; Phenols - analysis; Photochemistry; Pilot Projects; Plant Extracts - analysis; Plinia cauliflora; Polyphenols; Polyphenols - analysis; Single-Blind Method; small fruits; test meals; Young Adult; Myrciaria jaboticaba; Jaboticaba; HPLC-qTOF-MS; Polyphenols; Antioxidant capacity; HPLC-DAD-ECD-CAD; Insulin; Glycemia
• ISSN: 0308-8146; 1873-7072; 1873-7072
• DOI: 10.1016/j.foodchem.2016.04.142

•First full characterization of the phenolic composition of M. jaboticaba peel.•Polyphenols identification and antioxidant power were checked by LC-DAD-CAD-ECD-MS.•Anthocyanins were the major phenolics; ellagitannins had higher antioxidant power.•Jaboticaba intake increased serum antioxidant status.•Jaboticaba intake showed improvement on blood glucose and insulin response. Brazilian berries, such as Myrciaria jaboticaba (jaboticaba), are good sources of polyphenols with a recognized function in oxidative stress attenuation proved in non-clinical studies. In the present study, the polyphenols profile and their contribution to the antioxidant capacity of the jaboticaba peel were analyzed using high-performance liquid chromatography (HPLC) with photodiode array (DAD), electrochemical (ECD), charged aerosol (CAD), and mass spectrometry (MS) detections. Anthocyanins, ellagitannins and gallotannins, ellagic acid and derivatives, and flavonols were found in jaboticaba. Anthocyanins were the phenolics found in higher concentrations. However, ellagitannins were the main contributors to the total antioxidant capacity. Moreover, the effect of jaboticaba peel intake on antioxidant and glucose parameters in a single-blind placebo-controlled crossover study was investigated. The serum antioxidant capacity was significantly higher when the subjects had consumed the test meal containing jaboticaba. Serum insulin decreased subsequent to the second meal at 4h after jaboticaba peel consumption.