Harmonization of cortical thickness measurements across scanners and sites

• Published in: NeuroImage (Orlando, Fla.) Vol. 167; pp. 104 - 120
• Main Authors: Fortin, Jean-Philippe, Cullen, Nicholas, Sheline, Yvette I., Taylor, Warren D., Aselcioglu, Irem, Cook, Philip A., Adams, Phil, Cooper, Crystal, Fava, Maurizio, McGrath, Patrick J., McInnis, Melvin, Phillips, Mary L., Trivedi, Madhukar H., Weissman, Myrna M., Shinohara, Russell T.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.02.2018; Elsevier Limited
• Subjects: Adolescent; Adult; Age; Aged; Aged, 80 and over; Anxiety; Cerebral Cortex - anatomy & histology; Cerebral Cortex - diagnostic imaging; ComBat; Cortex; Cortical thickness; Data Interpretation, Statistical; Datasets; Datasets as Topic - standards; Female; Genomics; Harmonization; Humans; Inter-scanner; Magnetic resonance imaging; Magnetic Resonance Imaging - instrumentation; Magnetic Resonance Imaging - methods; Magnetic Resonance Imaging - standards; Male; Medical imaging; Mental depression; Middle Aged; Models, Theoretical; Multi-site; Multicenter Studies as Topic - instrumentation; Multicenter Studies as Topic - standards; Neuroimaging; Questionnaires; Scanners; Statistical analysis; Studies; Young Adult; United States > US; Texas; Massachusetts; Michigan; Cortical thickness; Inter-scanner; Multi-site; ComBat; Harmonization

With the proliferation of multi-site neuroimaging studies, there is a greater need for handling non-biological variance introduced by differences in MRI scanners and acquisition protocols. Such unwanted sources of variation, which we refer to as “scanner effects”, can hinder the detection of imaging...