Primary malignant mediastinal germ cell tumors: A single institutional experience

• Published in: South Asian Journal of Cancer Vol. 9; no. 1; pp. 27 - 29
• Main Authors: Mishra, Subhasis, Das Majumdar, Saroj Kumar, Sable, Mukund, Parida, Dillip Kumar
• Format: Journal Article
• Language: English
• Published: A-12, 2nd Floor, Sector 2, Noida-201301 UP, India Thieme Medical and Scientific Publishers Pvt. Ltd 01.01.2020; Wolters Kluwer India Pvt. Ltd; Medknow Publications and Media Pvt. Ltd; Wolters Kluwer - Medknow
• Subjects: extragonadal germ cell tumor; mediastinum; Metastasis; multimodality management; ORIGINAL ARTICLE: Genitourinary Cancers; Prognosis; seminoma; yolk-sac tumor; Extragonadal germ cell tumor; seminoma; mediastinum; multimodality management; yolk-sac tumor
• ISSN: 2278-330X; 2278-4306
• DOI: 10.4103/sajc.sajc_47_19

Abstract Bacground: Primary mediastinal malignant germ cell tumour (PMMGCT) is rare with unsatisfactory prognosis and pose difficulty in management due to lack of guidelines. Methods: All cases of PMMGCT diagnosed and treated between years 2014 to 2018 were retrospectively evaluated for clinico-pathological features, multimodality treatment and follow up. Results: Among a total of five PMMGCT cases, three were seminomatous and two were non seminomatous tumour [Yolk- sac tumour (n-1) and Mixed tumour (n-1)]. Four of these cases were non - metastatic with locally advancement and another one presented with metastasis to supraclavicular lymph node. All patients received platinum based induction chemotherapy. Post-induction chemotherapy, two cases of non seminomatous tumours underwent surgery. Among the three seminoma cases, one patient showed complete metabolic response; one with metastasis succumbed to the disease and the in-operable case of seminoma received local radiotherapy. Conclusion: PMMGCT needs a multi-disciplinary approach for appropriate diagnosis and management. Clinicopathological features like tumour site, extension, histopathological type, tumour stage and serum tumour marker are necessary for prognostication and decision making of further treatment plan.