Histone arginine methylation

Arginine methylation is a common posttranslational modification (PTM). This type of PTM occurs on both nuclear and cytoplasmic proteins, and is particularly abundant on shuttling proteins. In this review, we will focus on one aspect of this PTM: the diverse roles that arginine methylation of the cor...

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Bibliographic Details
Published inFEBS letters Vol. 585; no. 13; pp. 2024 - 2031
Main Authors Di Lorenzo, Alessandra, Bedford, Mark T.
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 07.07.2011
Subjects
Animals
Arginine - metabolism
Arginine methylation
CARM1
ChIP-seq
Histone code
Histones - metabolism
Humans
Methylation
Protein-Arginine N-Methyltransferases - genetics
Protein-Arginine N-Methyltransferases - metabolism
Tudor domain
ChIP-seq
Tudor domain
CARM1
Histone code
Arginine methylation
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Summary:Arginine methylation is a common posttranslational modification (PTM). This type of PTM occurs on both nuclear and cytoplasmic proteins, and is particularly abundant on shuttling proteins. In this review, we will focus on one aspect of this PTM: the diverse roles that arginine methylation of the core histone tails play in regulating chromatin function. A family of nine protein arginine methyltransferases (PRMTs) catalyze methylation reactions, and a subset target histones. Importantly, arginine methylation of histone tails can promote or prevent the docking of key transcriptional effector molecules, thus playing a central role in the orchestration of the histone code.
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ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2010.11.010