Cyclocondensation of o -phenylenediamines with α-ketothioesters: a novel approach for the synthesis of 2-acylbenzimidazoles
We herein present a novel and an unexpected method for the synthesis of α-ketothioesters by the reaction of pyrrolidine with α-oxodithioesters followed by treatment with methyl iodide in methanol. One of the synthetic applications of α-ketothioesters for the synthesis of 2-acylbenzimidazoles by acid...
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Published in | New journal of chemistry Vol. 48; no. 41; pp. 17998 - 18003 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Cambridge
Royal Society of Chemistry
21.10.2024
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Subjects | |
Online Access | Get full text |
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Summary: | We herein present a novel and an unexpected method for the synthesis of α-ketothioesters by the reaction of pyrrolidine with α-oxodithioesters followed by treatment with methyl iodide in methanol. One of the synthetic applications of α-ketothioesters for the synthesis of 2-acylbenzimidazoles by acid-catalyzed cyclocondensation with benzene-1,2-diamines is described. The probable mechanisms of formation of α-ketothioesters and 2-acylbenzimidazoles are proposed. |
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ISSN: | 1144-0546 1369-9261 |
DOI: | 10.1039/D4NJ03105A |