450-P: N-Terminal Pro-B Type Natriuretic Peptide Concentrations in Diabetic Cardiomyopathy—Baseline Data from the ARISE-HF Trial

Background: Diabetic Cardiomyopathy (DbCM) is a form of Stage B heart failure (HF). Concentrations of N-terminal pro-B type natriuretic peptide (NT-proBNP) may predict risk for HF progression in persons with DbCM. The ARISE-HF study (NCT04083339) is evaluating efficacy of AT-001, a highly selective...

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Published inDiabetes (New York, N.Y.) Vol. 72; no. Supplement_1; p. 1
Main Authors BUTLER, JAVED, DEL PRATO, STEFANO, EZEKOWITZ, JUSTIN, IBRAHIM, NASRIEN E., LAM, CAROLYN S., PERFETTI, RICCARDO, ROSENSTOCK, JULIO, WILSON TANG, W.H., URBINATI, ALESSIA, ZANNAD, FAIEZ, JANUZZI, JAMES L.
Format Journal Article
LanguageEnglish
Published New York American Diabetes Association 20.06.2023
Subjects
Aldehyde reductase
Blood pressure
Cardiomyopathy
Congestive heart failure
Diabetes
Diabetes mellitus (non-insulin dependent)
Echocardiography
Exercise
Peptides
Physical activity
Physical fitness
Physical training
Population studies
Ventricle
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Summary:Background: Diabetic Cardiomyopathy (DbCM) is a form of Stage B heart failure (HF). Concentrations of N-terminal pro-B type natriuretic peptide (NT-proBNP) may predict risk for HF progression in persons with DbCM. The ARISE-HF study (NCT04083339) is evaluating efficacy of AT-001, a highly selective aldose reductase inhibitor (AT-001) to improve exercise tolerance in affected patients. The aim of this analysis was to assess association between baseline NT-proBNP and cardiac status in type 2 diabetes participants with DbCM. Methods: Impaired exercise tolerance and baseline characteristics were evaluated in 679 patients with DbCM as a function of NT-proBNP at enrollment. Results: Median NT-proBNP in the overall study population was 71 ng/L (IQR 35-133). Baseline characteristics were similar across NT-proBNP concentrations, however, participants with higher NT-proBNP had higher left atrial volume (p<0.001) and higher right ventricular systolic pressure (p=0.04) on baseline echocardiogram. Higher NT-proBNP concentrations were associated with reduced physical activity reflected in lower PASE Score and a worse functional capacity reflected in lower peak VO2 (p<0.001) (Table 1). Conclusion: Among patients with DbCM, elevated NT-proBNP is associated with echocardiographic abnormalities and worse cardiac functional capacity and inversely associated with activity.
ISSN:0012-1797
1939-327X
DOI:10.2337/db23-450-P