Comparison of purse-string suture versus over-the-scope clip for gastric endoscopic full-thickness closure: traction and leak pressure testing in ex vivo porcine model

• Published in: BMC surgery Vol. 23; no. 1; pp. 20 - 10
• Main Authors: Matsui, Takanori, Kobara, Hideki, Nishiyama, Noriko, Nakatani, Kaho, Shi, Tingting, Tada, Naoya, Kozuka, Kazuhiro, Kobayashi, Nobuya, Chiyo, Taiga, Yachida, Tatsuo, Kondo, Akihiro, Kishino, Takayoshi, Okano, Keiichi, Fujihara, Shintaro, Uchita, Kunihisa, Hirasawa, Kingo, Masaki, Tsutomu
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 26.01.2023; BioMed Central; BMC
• Subjects: Air bubbles; Air leakage; Animal models; Animals; Care and treatment; Complications and side effects; Defects; Dehiscence; Endoscopic closure; Endoscopic full-thickness resection; Endoscopy; Esophagus; Gastrectomy; Gastrointestinal tumors; Laparoscopy; Methods; Mucosa; Over-the-scope clip; Patient outcomes; Pressure; Pressure gauges; Purse-string suture; Stomach; Stomach - surgery; Strings; Suture Techniques; Sutures; Swine; Thickness; Traction; Japan; Endoscopic closure; Over-the-scope clip; Purse-string suture; Endoscopic full-thickness resection
• ISSN: 1471-2482; 1471-2482
• DOI: 10.1186/s12893-023-01920-z

The recently developed endoscopic full-thickness resection technique requires reliable closure. The main closure methods are the purse-string suture (PSS) technique and over-the-scope clip (OTSC) technique; however, basic data on the closure strength of each technique are lacking. This study was performed to compare the closure strengths of these two methods in an ex vivo porcine model. In the traction test, a virtual 5-cm full-thickness closure line was closed by the following six methods three times each: conventional hemoclips, mucosal PSS, seromuscular PSS, mucosal OTSC, seromuscular OTSC, and surgical suture. The primary endpoint was the tension at the starting point of dehiscence, measured in Newtons (N) by an automatic traction machine. In the leak test, a 15-mm gastric full-thickness defect was closed by PSS or OTSC six times each, and the closed stomach was then pressurized in a water container. The primary endpoint was the leak pressure when air bubbles appeared. The secondary endpoints were the procedure time and presence of complete inverted closure. The mean tension was 2.16, 3.68, 5.15, 18.30, 19.30, and 62.40 N for conventional hemoclips, mucosal PSS, seromuscular PSS, mucosal OTSC, seromuscular OTSC, and surgical suture, respectively. Complete inverted closure was observed for seromuscular PSS, seromuscular OTSC, and surgical suture. The mean leak pressure was 13.7 and 24.8 mmHg in the PSS and OTSC group, respectively (P < 0.01). The mean procedure time was 541 and 169 s in the PSS and OTSC group, respectively (P < 0.01). Complete inverted closure was observed in OTSC alone. The OTSC, which allows complete inverted closure, showed greater closure strength than PSS. Considering the size limitation suitable for single OTSC, a therapeutic strategy for closing the larger size is further warranted.