The involvement of exosomes in the diagnosis and treatment of pancreatic cancer

• Published in: Molecular cancer Vol. 19; no. 1; pp. 132 - 9
• Main Authors: Ariston Gabriel, Abakundana Nsenga, Wang, Fang, Jiao, Qinlian, Yvette, Umwali, Yang, Xuemei, Al-Ameri, Samed Ahmed, Du, Lutao, Wang, Yun-shan, Wang, Chuanxin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 27.08.2020; BioMed Central; BMC
• Subjects: Angiogenesis; Biomarker; Biomarkers; Biomarkers, Tumor - genetics; Cancer diagnosis; Cancer metastasis; Cancer treatment; Cell cycle; Cell growth; Cell proliferation; Cell Proliferation - genetics; Cell signaling; Development and progression; Diagnosis; Disease; Exosomes; Exosomes - genetics; Extracellular vesicles; Extracellular Vesicles - genetics; Gastrointestinal diseases; Gene Expression Regulation, Neoplastic - genetics; Genes; Humans; Medical diagnosis; Medical prognosis; Metastases; Metastasis; MicroRNA; MicroRNAs; MicroRNAs - genetics; miRNA; mRNA; Pancreatic cancer; Pancreatic Neoplasms; Pancreatic Neoplasms - diagnosis; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - pathology; Proteins; Review; RNA, Messenger - genetics; Treatment; Tumor Microenvironment - genetics; Biomarker; Treatment; Exosomes; Pancreatic cancer
• ISSN: 1476-4598; 1476-4598
• DOI: 10.1186/s12943-020-01245-y

At the moment, pancreatic cancer is among the deadliest gastrointestinal diseases, and pancreatic cancer growth is a complex biological process that is based on different kinds of genes. Exosomes are extracellular vesicles containing microRNAs (miRNAs), messenger RNA (mRNA), and proteins, they act as the most prominent mediator of intercellular communication, and they regulate, instruct, and re-educate their surrounding microenvironment and target specific organs. Due to accumulative evidence proved that exosomes are involved in metastasis, cell proliferation, EMT, angiogenesis, and TME of pancreatic cancer, exosomes are crucial potential candidates to detect pancreatic cancer early. This review aims to convey the current understanding of the main functions employed by exosomes in early diagnosis and treatment of pancreatic cancer.