The choreography of neuroinflammation in Huntington's disease

Highlights • The etiology and role of inflammation in neurodegenerative diseases is unclear. • In HD, mutant Huntingtin in microglia promotes proinflammatory gene expression. • Peripheral immune cells appear to have little involvement in CNS inflammation in HD. • Cell-autonomous microglia reactivity...

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Bibliographic Details
Published inTrends in immunology Vol. 36; no. 6; pp. 364 - 373
Main Authors Crotti, Andrea, Glass, Christopher K
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2015
Elsevier Limited
Subjects
Allergy and Immunology
Alzheimer's disease
Animals
astrocytes
Brain
Cell division
Cytokines
Cytokines - immunology
Cytokines - metabolism
Gene expression
Humans
Huntingtin Protein
Huntington Disease - genetics
Huntington Disease - immunology
Huntington's disease
Immune system
Inflammation - genetics
Inflammation - immunology
macrophages
microglia
Microglia - immunology
Microglia - metabolism
Models, Immunological
Morphology
Mutation
Mutation - genetics
Mutation - immunology
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - immunology
Neurodegeneration
neuroinflammation
Neurons
Neurons - immunology
Neurons - metabolism
Oxidative stress
Pathogenesis
Plasma
Proteins
macrophages
astrocytes
Huntington's disease
neuroinflammation
microglia
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Summary:Highlights • The etiology and role of inflammation in neurodegenerative diseases is unclear. • In HD, mutant Huntingtin in microglia promotes proinflammatory gene expression. • Peripheral immune cells appear to have little involvement in CNS inflammation in HD. • Cell-autonomous microglia reactivity may impact HD inflammation and pathogenesis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2015.04.007