The Interaction of Deworming, Improved Sanitation, and Household Flooring with Soil-Transmitted Helminth Infection in Rural Bangladesh

• Published in: PLoS neglected tropical diseases Vol. 9; no. 12; p. e0004256
• Main Authors: Benjamin-Chung, Jade, Nazneen, Arifa, Halder, Amal K, Haque, Rashidul, Siddique, Abdullah, Uddin, Muhammed Salah, Koporc, Kim, Arnold, Benjamin F, Hubbard, Alan E, Unicomb, Leanne, Luby, Stephen P, Addiss, David G, Colford, Jr, John M
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.12.2015; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Animals; Anthelmintics - therapeutic use; Bangladesh - epidemiology; Child; Child, Preschool; Children; Cross-Sectional Studies; Estimates; Family Characteristics; Feces - parasitology; Female; Flooring; Funding; Health aspects; Health promotion; Helminthiasis; Helminthiasis - drug therapy; Helminthiasis - epidemiology; Helminthiasis - transmission; Helminths - classification; Helminths - isolation & purification; Households; Humans; Hygiene; Infant; Infections; Intestinal Diseases, Parasitic - drug therapy; Intestinal Diseases, Parasitic - epidemiology; Intestinal Diseases, Parasitic - transmission; Male; Methods; Middle Aged; Prevalence; Prevention; Principal components analysis; Ratios; Risk Factors; Rural areas; Rural Population; Sanitation; Sanitation - methods; Studies; Womens health; Young Adult; Bangladesh; ISW, Bangladesh
• ISSN: 1935-2735; 1935-2727; 1935-2735
• DOI: 10.1371/journal.pntd.0004256

The combination of deworming and improved sanitation or hygiene may result in greater reductions in soil-transmitted helminth (STH) infection than any single intervention on its own. We measured STH prevalence in rural Bangladesh and assessed potential interactions among deworming, hygienic latrines, and household finished floors. We conducted a cross-sectional survey (n = 1,630) in 100 villages in rural Bangladesh to measure three exposures: self-reported deworming consumption in the past 6 months, access to a hygienic latrine, and household flooring material. We collected stool samples from children 1-4 years, 5-12 years, and women 15-49 years. We performed mini-FLOTAC on preserved stool samples to detect Ascaris lumbricoides, Enterobius vermicularis, hookworm, and Trichuris trichiura ova. Approximately one-third (32%) of all individuals and 40% of school-aged children had an STH infection. Less than 2% of the sample had moderate/heavy intensity infections. Deworming was associated with lower Ascaris prevalence (adjusted prevalence ratio (PR) = 0.53; 95% CI 0.40, 0.71), but there was no significant association with hookworm (PR = 0.93, 95% CI 0.60, 1.44) or Trichuris (PR = 0.90, 95% CI 0.74, 1.08). PRs for hygienic latrine access were 0.91 (95% CI 0.67,1.24), 0.73 (95% CI 0.43,1.24), and 1.03 (95% CI 0.84,1.27) for Ascaris, hookworm, and Trichuris, respectively. Finished floors were associated with lower Ascaris prevalence (PR = 0.56, 95% CI 0.32, 0.97) but not associated with hookworm (PR = 0.48 95% CI 0.16,1.45) or Trichuris (PR = 0.98, 95% CI 0.72,1.33). Across helminths and combinations of exposures, adjusted prevalence ratios for joint exposures were consistently more protective than those for individual exposures. We found moderate STH prevalence in rural Bangladesh among children and women of childbearing age. This study is one of the first to examine independent and combined associations with deworming, sanitation, and hygiene. Our results suggest that coupling deworming with sanitation and flooring interventions may yield more sustained reductions in STH prevalence.