Conventional and contrast-enhanced ultrasound in the differential diagnosis of recurrent dermatofibrosarcoma protuberans and postoperative scar

• Published in: BMC cancer Vol. 24; no. 1; pp. 285 - 8
• Main Authors: Gong, Xia, Li, Jia, Ding, Angang, Zuo, Jiaxin, Rao, Yamin, Chen, Jun, Xiong, Ping
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.03.2024; BioMed Central; BMC
• Subjects: Analysis; Blood flow; Blood vessels; Cancer; Care and treatment; Color Doppler; Contrast agents; Contrast-enhanced ultrasound; Conventional ultrasound; Dermatofibroma; Dermatofibrosarcoma protuberans; Diagnosis; Diagnosis, Differential; Differential diagnosis; Doppler effect; Flow velocity; Hyperplasia; Methods; Pathology; Patients; Postoperative scar; Recurrent dermatofibrosarcoma protuberans; Relapse; Surgery; Tumors; Ultrasonic imaging; Ultrasound; Ultrasound imaging; Variance analysis; China; United States > US; Italy; Contrast-enhanced ultrasound; Postoperative scar; Color Doppler; Recurrent dermatofibrosarcoma protuberans; Conventional ultrasound
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-024-11991-7

Dermatofibrosarcoma protuberans (DFSP) has a high recurrence rate after resection. Because of the lack of specific manifestations, recurrent DFSP is easily misdiagnosed as post-resection scar. A few series have reported ultrasound findings of recurrent DFSP; moreover, the usefulness of contrast-enhanced ultrasound in differentiating recurrent DFSP has not been studied. We investigated conventional and contrast-enhanced ultrasound in the differential diagnosis of recurrent DFSP and post-resection scar. We retrospectively evaluated the findings of conventional and contrast-enhanced ultrasound in 34 cases of recurrent DFSP and 38 postoperative scars examined between January 2018 and December 2022. The depth and vascular density of recurrent DFSP were greater than those of postoperative scars (P < 0.05). On gray-scale ultrasound, recurrent DFSP lesions were more commonly irregular, heterogeneous, and hypoechoic, with finger-like projections and ill-defined borders. Postoperative scar was more likely to appear as hypoechoic and homogeneous with well-defined borders (P < 0.05). On color Doppler ultrasound, recurrent DFSP was more likely to feature rich arterial and venous blood flow, and postoperative scar was more likely to display poor blood flow (P < 0.05). On contrast-enhanced ultrasound, recurrent DFSP was more likely to feature heterogeneous hyper-enhancement, and postoperative scar was more likely to display homogeneous iso-enhancement (P < 0.05). Recurrent DFSP presented a higher peak and sharpness than postoperative scar (P < 0.05). Conventional and contrast-enhanced ultrasound produced distinct features of recurrent DFSP and post-resection scar, which could improve the accuracy of differential diagnosis.