Oral cavity-derived stem cells and preclinical models of jaw-bone defects for bone tissue engineering

• Published in: Stem cell research & therapy Vol. 14; no. 1; p. 39
• Main Authors: Zhao, Jie, Zhou, Ying-Hui, Zhao, Ya-Qing, Gao, Zheng-Rong, Ouyang, Ze-Yue, Ye, Qin, Liu, Qiong, Chen, Yun, Tan, Li, Zhang, Shao-Hui, Feng, Yao, Hu, Jing, Dusenge, Marie Aimee, Feng, Yun-Zhi, Guo, Yue
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.03.2023; BioMed Central; BMC
• Subjects: Alveolar bone; Analysis; Animal models; Animals; Bone and Bones; Bone density; Bone growth; Bone marrow; Bone Regeneration; Bone tissue engineering; Cell culture; Congenital diseases; Defects; Dental pulp; Dentin; Enamel; Jaw; Jaw-bone defects; Ligaments; Maxillofacial; Mouth; Oral cavity; Oral cavity-derived stem cells; Osteogenesis; Patient compliance; Quality of life; Regeneration; Review; Stem cell research; Stem Cells; Teeth; Tissue Engineering; Jaw-bone defects; Bone tissue engineering; Models; Oral cavity-derived stem cells
• ISSN: 1757-6512; 1757-6512
• DOI: 10.1186/s13287-023-03265-z

Jaw-bone defects caused by various diseases lead to aesthetic and functional complications, which can seriously affect the life quality of patients. Current treatments cannot fully meet the needs of reconstruction of jaw-bone defects. Thus, the research and application of bone tissue engineering are a "hot topic." As seed cells for engineering of jaw-bone tissue, oral cavity-derived stem cells have been explored and used widely. Models of jaw-bone defect are excellent tools for the study of bone defect repair in vivo. Different types of bone defect repair require different stem cells and bone defect models. This review aimed to better understand the research status of oral and maxillofacial bone regeneration. Data were gathered from PubMed searches and references from relevant studies using the search phrases "bone" AND ("PDLSC" OR "DPSC" OR "SCAP" OR "GMSC" OR "SHED" OR "DFSC" OR "ABMSC" OR "TGPC"); ("jaw" OR "alveolar") AND "bone defect." We screened studies that focus on "bone formation of oral cavity-derived stem cells" and "jaw bone defect models," and reviewed the advantages and disadvantages of oral cavity-derived stem cells and preclinical model of jaw-bone defect models. The type of cell and animal model should be selected according to the specific research purpose and disease type. This review can provide a foundation for the selection of oral cavity-derived stem cells and defect models in tissue engineering of the jaw bone.