Adhesion of Insect Cells Expressing the Feline Herpesvirus Type 1 Hemagglutinin (gD) to Feline Cell Lines

• Published in: Journal of Veterinary Medical Science Vol. 59; no. 3; pp. 217 - 219
• Main Authors: MAEDA, Ken, ONO, Mitsuru, KAWAGUCHI, Yasushi, OKAZAKI, Katsunori, YOKOYAMA, Naoaki, TOHYA, Yukinobu, MIKAMI, Takeshi
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.03.1997; Japan Science and Technology Agency
• Subjects: adhesion; Alphaherpesvirinae - immunology; Animals; Antibodies, Monoclonal - analysis; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - pharmacology; Antigens, Viral - analysis; Antigens, Viral - immunology; Cat Diseases - immunology; Cat Diseases - pathology; Cats - embryology; Cats - immunology; Cattle; Cell Adhesion - drug effects; Cell Adhesion - physiology; Cell Line; Dogs; Fetus - cytology; FHV-1 gD; hemagglutinin; Hemagglutinins, Viral - analysis; Hemagglutinins, Viral - metabolism; Herpesviridae Infections - immunology; Herpesviridae Infections - pathology; Herpesviridae Infections - veterinary; Herpesvirus; Insecta - cytology; Insecta - immunology; Kidney - cytology; Kidney - embryology; Moths - cytology; Moths - immunology; Swine
• ISSN: 0916-7250; 1347-7439
• DOI: 10.1292/jvms.59.217

Feline herpesvirus type 1 (FHV-1) gD-expressing Sf9 cells adhered to two feline cell lines, but not to the porcine, bovine, or canine cell lines tested. In addition, this adhesion activity was inhibited by a monoclonal antibody against FHV-1 gD. These results showed that the FHV-1 gD might bind to a specific-molecule(s) on the surface of feline cell lines. We discussed a possible importance of the FHV-1 gD in host cell restriction to FHV-1 infection.