Clinicomics-guided distant metastasis prediction in breast cancer via artificial intelligence

• Published in: BMC cancer Vol. 23; no. 1; pp. 239 - 16
• Main Authors: Zhang, Chao, Qi, Lisha, Cai, Jun, Wu, Haixiao, Xu, Yao, Lin, Yile, Li, Zhijun, Chekhonin, Vladimir P., Peltzer, Karl, Cao, Manqing, Yin, Zhuming, Wang, Xin, Ma, Wenjuan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 14.03.2023; BioMed Central; BMC
• Subjects: Accuracy; Artificial Intelligence; Bone Neoplasms - diagnostic imaging; Bone Neoplasms - secondary; Breast Cancer; Breast Neoplasms - pathology; Complications and side effects; Female; Humans; Lymphatic system; Magnetic resonance imaging; Medical prognosis; Metastases; Metastasis; Nomograms; Nomography (Mathematics); Patients; Prediction; Prediction models; Prognosis; Radiomics; Retrospective Studies; Risk factors; Software; Tumors; Ultrasonic imaging; China; Metastasis; Image; Breast Cancer; Artificial Intelligence; Prediction
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-023-10704-w

Breast cancer has become the most common malignant tumour worldwide. Distant metastasis is one of the leading causes of breast cancer-related death. To verify the performance of clinicomics-guided distant metastasis risk prediction for breast cancer via artificial intelligence and to investigate the accuracy of the created prediction models for metachronous distant metastasis, bone metastasis and visceral metastasis. We retrospectively enrolled 6703 breast cancer patients from 2011 to 2016 in our hospital. The figures of magnetic resonance imaging scanning and ultrasound were collected, and the figures features of distant metastasis in breast cancer were detected. Clinicomics-guided nomogram was proven to be with significant better ability on distant metastasis prediction than the nomogram constructed by only clinical or radiographic data. Three clinicomics-guided prediction nomograms on distant metastasis, bone metastasis and visceral metastasis were created and validated. These models can potentially guide metachronous distant metastasis screening and lead to the implementation of individualized prophylactic therapy for breast cancer patients. Our study is the first study to make cliniomics a reality. Such cliniomics strategy possesses the development potential in artificial intelligence medicine.