Oral infections and systemic disease—an emerging problem in medicine

• Published in: Clinical microbiology and infection Vol. 13; no. 11; pp. 1041 - 1047
• Main Authors: Rautemaa, R., Lauhio, A., Cullinan, M.P., Seymour, G.J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Elsevier Ltd 01.11.2007; Blackwell Publishing Ltd; Blackwell
• Subjects: Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiseptics; Bacteraemia; Bacterial diseases; Bacterial Infections - complications; Bacterial sepsis; Biological and medical sciences; Health Status; Human bacterial diseases; Human immunodeficiency virus; Humans; Infectious diseases; Medical sciences; Mouth Diseases - complications; odontogenic infections; oral disease; Oral Hygiene - methods; Pharmacology. Drug treatments; prevention; review; triclosan; Bacteraemia; odontogenic infections; triclosan; oral disease; review; prevention; Bacteremia; Infection; Prevention; Chlorine Organic compounds; Systemic disease; Bacteriosis; Phenols; Oral cavity disease; Triclosan; Disinfecting agent; Bibliographic review
• ISSN: 1198-743X; 1469-0691
• DOI: 10.1111/j.1469-0691.2007.01802.x

The relationship between oral and general health has been increasingly recognised during the past two decades. Several epidemiological studies have linked poor oral health with cardiovascular disease, poor glycaemic control in diabetics, low birth-weight pre-term babies, and a number of other conditions, including rheumatoid arthritis and osteoporosis. Oral infections are also recognised as a problem for individuals suffering from a range of chronic conditions, including cancer and infection with human immunodeficiency virus, as well as patients with ventilator-associated pneumonia. This review considers the systemic consequences of odontogenic infections and the possible mechanisms by which oral infection and inflammation can contribute to cardiovascular disease, as well as the oral conditions associated with medically compromised patients. A large number of clinical studies have established the clinical efficacy of topical antimicrobial agents, e.g., chlorhexidine and triclosan, in the prevention and control of oral disease, especially gingivitis and dental plaque. The possible risks of antimicrobial resistance are a concern, and the benefits of long-term use of triclosan require further evaluation. Oral infections have become an increasingly common risk-factor for systemic disease, which clinicians should take into account. Clinicians should increase their knowledge of oral diseases, and dentists must strengthen their understanding of general medicine, in order to avoid unnecessary risks for infection that originate in the mouth.