Amaranth (Amaranthus cruentus L.) and canola (Brassica napus L.) oil impact on the oxidative metabolism of neutrophils in the obese patients

• Published in: Pharmaceutical biology Vol. 57; no. 1; pp. 140 - 144
• Main Authors: Kanikowska, Dominika, Kanikowska, Alina, Rutkowski, Rafał, Włochal, Małgorzata, Orzechowska, Zofia, Juchacz, Aldona, Zawada, Agnieszka, Grzymisławski, Marian, Roszak, Magdalena, Sato, Maki, Bręborowicz, Andrzej, Witowski, Janusz
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.01.2019; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Amaranth; Antioxidants; Body mass index; Canola; Dietary supplements; Leukocytes (neutrophilic); Leukocytes (polymorphonuclear); Metabolism; Neutrophil oxidative burst; Neutrophils; Nutrient deficiency; Nutritive value; Obesity; Oxidation; Oxidative metabolism; Oxidative stress; plant oil; Reactive oxygen species; Vegetable oils; Neutrophil oxidative burst; obesity; plant oil
• ISSN: 1388-0209; 1744-5116
• DOI: 10.1080/13880209.2019.1569696

Context: Amaranth and canola oils have been used traditionally. Amaranth has been identified as being of interest because of its outstanding nutritive value. Amaranth oil is a rich source of highly unsaturated fats and so could be a valuable dietary alternative for individuals affected with obesity. Reactive oxygen species (ROS) are postulated to be involved in systemic inflammation and oxidative stress. Activated polymorphonuclear neutrophils (PMNs) generate high amounts of reactive oxygen species. Objective: Our study investigates the impact of amaranth and canola oils supplementation on oxidative metabolism in patients with obesity. We hypothesized that, due to its lipid-lowering and antioxidant properties, amaranth and canola oil would protect against oxidative stress. Materials and methods: We tested 19 obese patients [body mass index (BMI) = 41.1 ± 7.8 kg/m 2 , (mean ± SD)]. The protocol consisted of two stages: a run-in phase of 2 weeks and an experimental stage - canola or amaranth oil supplementation (20 mL/d) with calorie restriction diet for 3 weeks. The neutrophil oxidative burst was expressed by fluorescence intensity (IF). Results: The oxidative burst had increased significantly at the end of treatment in both groups IF: (21.4 ± 11.15 vs. 35.9 ± 20.3; mean ± SD) p < 0.05. The levels of IF were significantly higher in neutrophils of patients who received canola oil (41.05 ± 25.3) compared to those who received amaranth oil (28.4 ± 11.8) p < 0.05. Conclusions: Canola oil exerts possible effects on oxidative burst activity in neutrophils in vivo conditions.