First case report of myopericarditis linked to Campylobacter coli enterocolitis

• Published in: BMC infectious diseases Vol. 17; no. 1; p. 8
• Main Authors: Moffatt, Cameron R M, Moloi, Soniah B, Kennedy, Karina J
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.01.2017; BioMed Central
• Subjects: Campylobacter; Campylobacter coli - isolation & purification; Campylobacter infections; Campylobacter Infections - diagnosis; Cardiology; Case Report; Case reports; Complications and side effects; Echocardiography; Electrocardiogram; Electrocardiography; Enterocolitis - complications; Enterocolitis - microbiology; Enzymes; Epidemiology; Female; Fetuses; Guillain-Barre syndrome; Humans; Illnesses; Infections; Kinases; Middle Aged; Myocarditis - diagnosis; Myocarditis - microbiology; Nonsteroidal anti-inflammatory drugs; Pain; Patients; Pericarditis; Pericarditis - diagnosis; Pericarditis - microbiology; Pericardium; Risk factors; Ultrasonic imaging; Campylobacter infections; Female; Case report; Myopericarditis; Etiology; Campylobacter coli
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-016-2115-9

Campylobacter spp. are a common cause of mostly self-limiting enterocolitis. Although rare, pericarditis and myopericarditis have been increasingly documented as complications following campylobacteriosis. Such cases have occurred predominantly in younger males, and involved a single causative species, namely Campylobacter jejuni. We report the first case of myopericarditis following Campylobacter coli enterocolitis, with illness occurring in an immunocompetent middle-aged female. A 51-yo female was admitted to a cardiology unit with a 3-days history of chest pain. The woman had no significant medical history or risk factors for cardiac disease, nor did she report any recent overseas travel. Four days prior to the commencement of chest pain the woman had reported onset of an acute gastrointestinal illness, passing 3-4 loose stools daily, a situation that persisted at the time of presentation. Physical examination showed the woman's vital signs to be essentially stable, although she was noted to be mildly tachycardic. Laboratory testing showed mildly elevated C-reactive protein and a raised troponin I in the absence of elevation of the serum creatinine kinase. Electrocardiography (ECG) demonstrated concave ST segment elevations, and PR elevation in aVR and depression in lead II. Transthoracic echocardiogram (TTE) revealed normal biventricular size and function with no significant valvular abnormalities. There were no left ventricular regional wall motion abnormalities. No pericardial effusion was present but the pericardium appeared echodense. A diagnosis of myopericarditis was made on the basis of chest pain, typical ECG changes and troponin rise. The chest pain resolved and she was discharged from hospital after 2-days of observation, but with ongoing diarrhoea. Following discharge, a faecal sample taken during the admission, cultured Campylobacter spp. Matrix assisted laser desorption ionization time-of-flight (Bruker) confirmed the cultured isolate as C. coli. We report the first case of myopericarditis with a suggested link to an antecedent Campylobacter coli enterocolitis. Although rare, myopericarditis is becoming increasingly regarded as a complication following campylobacteriosis. Our report highlights potential for pericardial disease beyond that attributed to Campylobacter jejuni. However uncertainty regarding pathogenesis, coupled with a paucity of population level data continues to restrict conclusions regarding the strength of this apparent association.