Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects

• Published in: Stem cell research & therapy Vol. 13; no. 1; pp. 146 - 21
• Main Authors: Li, Meirong, Jiang, Yufeng, Hou, Qian, Zhao, Yali, Zhong, Lingzhi, Fu, Xiaobing
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.04.2022; BioMed Central; BMC
• Subjects: Apoptosis; Bone marrow; Cell culture; Cell Differentiation; DNA damage; Engraftment; Genes; Genetic engineering; Growth factors; Health aspects; Humans; Hypoxia; Immunomodulation; Individualized MSCs therapy; Mesenchymal stem cell; Mesenchymal Stem Cell Transplantation - methods; Mesenchymal Stem Cells; Oxidative stress; Physiology; Pre-activation; Review; Senescence; Simulation; Stem cells; Therapeutic potential; Transplantation; Type 2 diabetes; Umbilical cord; Mesenchymal stem cell; Individualized MSCs therapy; Pre-activation; Therapeutic potential

Mesenchymal stem cell (MSC)-based therapy has been considered as a promising approach targeting a variety of intractable diseases due to remarkable multiple effect of MSCs, such as multilineage differentiation, immunomodulatory property, and pro-regenerative capacity. However, poor engraftment, low...