Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects

Mesenchymal stem cell (MSC)-based therapy has been considered as a promising approach targeting a variety of intractable diseases due to remarkable multiple effect of MSCs, such as multilineage differentiation, immunomodulatory property, and pro-regenerative capacity. However, poor engraftment, low...

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Published inStem cell research & therapy Vol. 13; no. 1; pp. 146 - 21
Main Authors Li, Meirong, Jiang, Yufeng, Hou, Qian, Zhao, Yali, Zhong, Lingzhi, Fu, Xiaobing
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 04.04.2022
BioMed Central
BMC
Subjects
Apoptosis
Bone marrow
Cell culture
Cell Differentiation
DNA damage
Engraftment
Genes
Genetic engineering
Growth factors
Health aspects
Humans
Hypoxia
Immunomodulation
Individualized MSCs therapy
Mesenchymal stem cell
Mesenchymal Stem Cell Transplantation - methods
Mesenchymal Stem Cells
Oxidative stress
Physiology
Pre-activation
Review
Senescence
Simulation
Stem cells
Therapeutic potential
Transplantation
Type 2 diabetes
Umbilical cord
Mesenchymal stem cell
Individualized MSCs therapy
Pre-activation
Therapeutic potential
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Summary:Mesenchymal stem cell (MSC)-based therapy has been considered as a promising approach targeting a variety of intractable diseases due to remarkable multiple effect of MSCs, such as multilineage differentiation, immunomodulatory property, and pro-regenerative capacity. However, poor engraftment, low survival rate of transplanted MSC, and impaired donor-MSC potency under host age/disease result in unsatisfactory therapeutic outcomes. Enhancement strategies, including genetic manipulation, pre-activation, and modification of culture method, have been investigated to generate highly functional MSC, and approaches for MSC pre-activation are highlighted. In this review, we summarized the current approaches of MSC pre-activation and further classified, analysed the scientific principles and main characteristics of these manipulations, and described the pros and cons of individual pre-activation strategies. We also discuss the specialized tactics to solve the challenges in this promising field so that it improves MSC therapeutic functions to serve patients better.
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ISSN:1757-6512
1757-6512
DOI:10.1186/s13287-022-02822-2