Risk factors associated with multidrug-resistant tuberculosis (MDR-TB) in a tertiary armed force referral and teaching hospital, Ethiopia

• Published in: BMC infectious diseases Vol. 18; no. 1; p. 249
• Main Authors: Demile, Biresaw, Zenebu, Amare, Shewaye, Haile, Xia, Siqing, Guadie, Awoke
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 31.05.2018; BioMed Central; BMC
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Analysis; Antibiotics; Antitubercular Agents - therapeutic use; Armed force; Armed forces; Bacteria; Bivariate analysis; Body mass; Body mass index; Body size; Care and treatment; Cross-Sectional Studies; Data processing; Deoxyribonucleic acid; Disease; Diseases; DNA; Drug resistance; Drug susceptibility; Ethiopia; Ethiopia - epidemiology; Ethiopians; Female; Health aspects; Health risks; History of medicine; HIV; Hospitals, Military - statistics & numerical data; Hospitals, Teaching - statistics & numerical data; Human immunodeficiency virus; Humans; Infections; Infectious diseases; Leprosy; Male; Microbial Sensitivity Tests; Middle Aged; Military Personnel - statistics & numerical data; Multidrug resistance; Multidrug resistant organisms; Mycobacterium tuberculosis; Mycobacterium tuberculosis - isolation & purification; Patients; Population (statistical); Public health; Regression analysis; Resistance factors; Risk analysis; Risk Factors; Sexually transmitted diseases; Smear; Social sciences; Statistical analysis; Statistical tests; STD; Tertiary Care Centers - statistics & numerical data; Tuberculosis; Tuberculosis, Multidrug-Resistant - drug therapy; Tuberculosis, Multidrug-Resistant - epidemiology; Viruses; Young Adult; Ethiopia; China; Swaziland; Africa; Zimbabwe; Nigeria; Addis Ababa Ethiopia; India; Tuberculosis; Drug susceptibility; Armed force; Ethiopia; Risk factors
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-018-3167-9

Ethiopia is one of the world health organization defined higher tuberculosis (TB) burden countries where the disease remains a massive public health threat. This study aimed to identify the prevalence and associated factors of multidrug-resistant tuberculosis (MDR-TB) using all armed force and civilian TB attendants in a tertiary level armed force hospital, where data for MDR-TB are previously unpublished. Cross-sectional study was conducted from September 2014 to August 2015 in a tertiary level Armed Force Referral and Teaching Hospital (AFRTH), Ethiopia. Armed force members (n = 251) and civilians (n = 130) which has been undergone TB diagnosis at AFRTH were included. All the specimens collected were subjected to microscopic smear observation, culture growth and drug susceptibility testing. Data were analyzed using statistical package for social sciences following binary logistic regression and Chi-square. P-values < 0.05 were considered statistically significant. Among 381 TB patients, 355 (93.2%) new and 26 (6.8%) retreatment cases were identified. Culture and smear positive TB cases were identified in 297 (77.9%) and 252 (66.1%) patients, respectively. The overall prevalence of MDR-TB in AFRTH was found 1.8% (1.3% for armed force members and 0.5% for civilian patients) all of which were previously TB treated cases. The entire treatment success rates were 92.6% achieved highest in the armed force (active and pension) than the civilian patients. The failure and dead cases were also found 2.5 and 4.6%, respectively. Using bivariate analysis, category of attendants and TB contact history were strong predictors of MDR-TB in armed force and civilian patients. Moreover, human immunodeficiency virus (HIV) infection also identified a significant (OR = 14.6; 95% CI = 2.3-92.1; p = 0.004) predicting factor for MDR-TB in armed force members. However, sex, age and body mass index were not associated factor for MDR-TB. In AFRTH, lower prevalence of MDR-TB was identified in armed force and civilian patients that were significantly associated with category of attendants, HIV infection and TB contact history. Considering armed force society as one segment of population significantly helps to plan a better MDR-TB control management, especially for countries classified as TB high burden country.