One Health drivers of antibacterial resistance: Quantifying the relative impacts of human, animal and environmental use and transmission

• Published in: One health Vol. 12; p. 100220
• Main Authors: Booton, Ross D., Meeyai, Aronrag, Alhusein, Nour, Buller, Henry, Feil, Edward, Lambert, Helen, Mongkolsuk, Skorn, Pitchforth, Emma, Reyher, Kristen K., Sakcamduang, Walasinee, Satayavivad, Jutamaad, Singer, Andrew C., Sringernyuang, Luechai, Thamlikitkul, Visanu, Vass, Lucy, Avison, Matthew B., Chantong, Boonrat, Charoenlap, Nisanart, Couto, Natacha, Dulyayangkul, Punyawee, Gibbon, Marjorie J., Gould, Virginia C., Montrivade, Varapon, Phoonsawad, Kornrawan, Rangkadilok, Nuchanart, Ratanakorn, Parntep, Sirikanchana, Kwanrawee, Suriyo, Tawit, Suwanpakdee, Sarin, Turner, Katherine M.E., Wichuwaranan, Kantima, Wiratsudakul, Anuwat
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2021; Elsevier
• Subjects: animal health; Antibacterial resistance; Antibacterial usage; antibiotic resistance; beta-lactamase; beta-lactamase bacteria; digestive system; human health; humans; long term effects; Mathematical model; morbidity; One health; Research Paper; Thailand; Transmission; Thailand; Antibacterial usage; One health; Antibacterial resistance; Mathematical model; Thailand; Transmission
• ISSN: 2352-7714; 2352-7714
• DOI: 10.1016/j.onehlt.2021.100220

Antibacterial resistance (ABR) is a major global health security threat, with a disproportionate burden on lower-and middle-income countries (LMICs). It is not understood how ‘One Health’, where human health is co-dependent on animal health and the environment, might impact the burden of ABR in LMICs. Thailand's 2017 “National Strategic Plan on Antimicrobial Resistance” (NSP-AMR) aims to reduce AMR morbidity by 50% through 20% reductions in human and 30% in animal antibacterial use (ABU). There is a need to understand the implications of such a plan within a One Health perspective. A model of ABU, gut colonisation with extended-spectrum beta-lactamase (ESBL)-producing bacteria and transmission was calibrated using estimates of the prevalence of ESBL-producing bacteria in Thailand. This model was used to project the reduction in human ABR over 20 years (2020–2040) for each One Health driver, including individual transmission rates between humans, animals and the environment, and to estimate the long-term impact of the NSP-AMR intervention. The model predicts that human ABU was the most important factor in reducing the colonisation of humans with resistant bacteria (maximum 65.7–99.7% reduction). The NSP-AMR is projected to reduce human colonisation by 6.0–18.8%, with more ambitious targets (30% reductions in human ABU) increasing this to 8.5–24.9%. Our model provides a simple framework to explain the mechanisms underpinning ABR, suggesting that future interventions targeting the simultaneous reduction of transmission and ABU would help to control ABR more effectively in Thailand. •We present a novel mathematical model of human, animal and environment ABR transmission and ABU.•Human ABU was identified as the main driver of human ABR.•Resistance within humans was primarily driven by human activity rather than animal or environmental usage or transmission.•One Health interventions which consider human, animal and environmental transmission and usage can yield the highest impact.