Associations between nutritional factors and KRAS mutations in colorectal cancer: a systematic review

• Published in: BMC cancer Vol. 20; no. 1; pp. 696 - 21
• Main Authors: El Asri, Achraf, Zarrouq, Btissame, El Kinany, Khaoula, Bouguenouch, Laila, Ouldim, Karim, El Rhazi, Karima
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 28.07.2020; BioMed Central; BMC
• Subjects: Acrylamide - adverse effects; Alcoholic beverages; Analysis; Beverages - adverse effects; Caffeine; Cetuximab; Coffee; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - genetics; Consumption; Dairy products; Dairy Products - adverse effects; Diet; Diet - adverse effects; Dietary Fats - adverse effects; Dietary Fiber; Dietary Proteins - adverse effects; Epidemiology; Food; Food - adverse effects; Foods; Fruit; Fruits; Gastrointestinal diseases; Genes, ras; Genetic aspects; Humans; K-Ras protein; KRAS mutations; Meat; Medical prognosis; Mutation; Nutrients; Nutrients - adverse effects; Nutrition research; Quality; Review; Reviews; Sarcoma; Studies; Systematic review; Tea; Tumors; Vegetables; Netherlands; KRAS mutations; Nutrients; Foods; Diet; Colorectal cancer
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-020-07189-2

Between 30 and 50% of colon tumors have mutations in the Kirsten-ras (KRAS) gene, which have a large nutritional attributable risk. Despite its high frequency in colorectal cancer (CRC), data to support specific associations between KRAS mutations in CRC and diet are sparse. Here, we conducted a systematic review to summarize the current epidemiological evidence on the association between various dietary factors and KRAS mutations. PubMed, Science Direct, and Cochrane databases were searched for relevant studies published until December 31, 2019, using inclusion and exclusion criteria in accordance with PRISMA guidelines. We analyzed the studies to find associations between nutritional factors and CRC tumors with KRAS mutations in humans. We identified 28 relevant studies to include in this systematic review. In-depth analyses showed unclear associations between nutritional factors and KRAS mutations in CRC. Most epidemiological studies in the same nutrient or food often reported conflicting and/or inconclusive findings, whereas for some dietary factors, the results were homogeneous. Further research using a more robust prospective cohort study is needed to lend more credence to the epidemiological associations found between KRAS mutations and dietary factors.