Shining the light on mesenchymal stem cell-derived exosomes in breast cancer

• Published in: Stem cell research & therapy Vol. 14; no. 1; p. 21
• Main Authors: Al-Awsi, Ghaidaa Raheem Lateef, Alsaikhan, Fahad, Margiana, Ria, Ahmad, Irfan, Patra, Indrajit, Najm, Mazin A A, Yasin, Ghulam, Rasulova, Iroda, Hammid, Ali Thaeer, Kzar, Hamzah H, Al-Gazally, Moaed E, Siahmansouri, Homayoon
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.02.2023; BioMed Central; BMC
• Subjects: Angiogenesis; Antigens; Biosynthesis; Breast cancer; Breast Neoplasms - pathology; Cell death; Cell differentiation; Cell interactions; Cell proliferation; Cells; Communication; Development and progression; Exosome; Exosomes; Exosomes - metabolism; Extracellular vesicles; Female; Health aspects; Humans; Lipids; Mesenchymal stem cell; Mesenchymal stem cells; Mesenchymal Stem Cells - metabolism; Metastases; MicroRNAs; MicroRNAs - metabolism; miRNA; Proteins; Review; Roles; Stem cells; Tumor; Tumors; Canada; Mesenchymal stem cell; Extracellular vesicles; Tumor; Breast cancer; Exosome
• ISSN: 1757-6512; 1757-6512
• DOI: 10.1186/s13287-023-03245-3

In women, breast cancer (BC) is the second most frequently diagnosed cancer and the leading cause of cancer death. Mesenchymal stem cells (MSCs) are a subgroup of heterogeneous non-hematopoietic fibroblast-like cells that have the ability to differentiate into multiple cell types. Recent studies stated that MSCs can migrate into the tumor sites and exert various effect on tumor growth and development. Multiple researches have demonstrated that MSCs can favor tumor growth, while other groups have indicated that MSCs inhibit tumor development. Emerging evidences showed exosomes (Exo) as a new mechanism of cell communication which are essential for the crosstalk between MSCs and BC cells. MSC-derived Exo (MSCs-Exo) could mimic the numerous effects on the proliferation, metastasis, and drug response through carrying a wide scale of molecules, such as proteins, lipids, messenger RNAs, and microRNAs to BC cells. Consequently, in the present literature, we summarized the biogenesis and cargo of Exo and reviewed the role of MSCs-Exo in development of BC.