Role of B cells in common variable immune deficiency

Common variable immune deficiency is a heterogeneous immune deficiency characterized by reduced serum immunoglobulins and a lack of antibodies. As the name implies, B-cell defects are variably defective. In particular, peripheral blood isotype-switched CD27 + memory B cells are reduced in number and...

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Published inExpert review of clinical immunology Vol. 5; no. 5; pp. 557 - 564
Main Authors Ahn, Sam, Cunningham-Rundles, Charlotte
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 01.09.2009
Expert Reviews Ltd
Informa Healthcare
Subjects
antibody
B cell
B cells
CD19 antigen
Cell survival
CVID
ICOS protein
Immunodeficiency
Immunoglobulins
Immunological memory
Lymphadenopathy
Lymphocytes B
memory B cell
Memory cells
Peripheral blood
Physiological aspects
primary immune deficiency
Reviews
Risk factors
Splenomegaly
Toll-like receptors
United States
Online AccessGet full text
ISSN1744-666X
1744-8409
DOI10.1586/eci.09.43

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Summary:Common variable immune deficiency is a heterogeneous immune deficiency characterized by reduced serum immunoglobulins and a lack of antibodies. As the name implies, B-cell defects are variably defective. In particular, peripheral blood isotype-switched CD27 + memory B cells are reduced in number and have been the basis of several classification schemes. A lack of these B cells has been associated with selected clinical conditions, including immune cytopenias, splenomegaly, granulomatous disease and lymphadenopathy. Genetic defects in ICOS, CD19 and TACI have been described. In addition to defects in the production or survival of memory B cells, in most subjects, B cells have defects in Toll-like receptor signaling.
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ISSN:1744-666X
1744-8409
DOI:10.1586/eci.09.43