Amount of maternal rotavirus-specific antibodies influence the outcome of rotavirus vaccination of newborn mice with virus-like particles

• Published in: Vaccine Vol. 26; no. 6; pp. 778 - 785
• Main Authors: Johansson, E, Istrate, C, Charpilienne, A, Cohen, J, Hinkula, J, Poncet, D, Svensson, L, Johansen, K
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 06.02.2008; Elsevier; Elsevier Limited
• Subjects: Administration, Oral; Allergy and Immunology; Animals; Antibodies, Viral - blood; Antibodies, Viral - immunology; Antibody Specificity; Antigens; Applied microbiology; Biological and medical sciences; Dams; Diarrhea; Female; Fundamental and applied biological sciences. Psychology; Hogs; Immunity (Disease); Immunity, Maternally-Acquired - immunology; Immunization; Immunoglobulin G - blood; Immunoglobulin G - immunology; Infections; Injections, Subcutaneous; Life Sciences; MEDICIN; Medicin och hälsovetenskap; MEDICINE; Mice; Mice, Inbred BALB C; Microbiology; Miscellaneous; Neonatal immunization; Offspring; PCPP; Pregnancy; Rotavirus; Rotavirus - immunology; Rotavirus Infections - blood; Rotavirus Infections - immunology; Rotavirus Vaccines - administration & dosage; Rotavirus Vaccines - immunology; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Virology; Virus-like particles; Viruses; Rotavirus; Neonatal immunization; PCPP; Virus-like particles; Human; Immunization; Prognosis; Virus like particle; Vaccination; Rodentia; Vaccine; Reoviridae; Virus; Vertebrata; Mammalia; Newborn; Mouse; VIRUS-LIKE PARTICLES; IMMUNOLOGIE; NEONATAL IMMUNIZATION
• ISSN: 0264-410X; 1873-2518; 1873-2518; 0264-410X
• DOI: 10.1016/j.vaccine.2007.11.089

Summary In presence of low or high levels of rotavirus-specific maternal antibodies, the ability of newborn mice to respond to immunization with rotavirus RF 8*-2/6/7 VLPs, was evaluated. After parenteral vaccination, 100% of offspring born to low-antibody-titer dams developed rotavirus-specific IgG antibodies ( n = 7). In contrast, only 25% of offsprings born to high-antibody-titer dams responded to parenteral immunization ( n = 12). When comparing parenteral versus oral immunization in offspring to low-antibody-titer dams only 45% responded after oral immunization ( n = 6). In conclusion, the response to parenteral immunization was not hampered by the presence of low levels of maternal antibodies induced by a natural infection while oral immunization was impaired. However, high levels of maternal antibodies impaired the response to parenteral immunization.