Cross-species studies of orbitofrontal cortex and value-based decision-making

• Published in: Nature neuroscience Vol. 15; no. 1; pp. 13 - 19
• Main Author: Wallis, Jonathan D
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.01.2012; Nature Publishing Group
• Subjects: 631/378/1457/1945; 631/378/2629/1409; 631/443/376; 692/700/1421/65; Animal Genetics and Genomics; Animals; Behavioral Sciences; Biological Techniques; Biomedical and Life Sciences; Biomedicine; Decision making; Decision Making - physiology; Frontal Lobe - physiology; Haplorhini; Humans; Neurobiology; Neurosciences; Physiological aspects; Prefrontal cortex; review-article; Social Values; United States > US; California
• ISSN: 1097-6256; 1546-1726
• DOI: 10.1038/nn.2956

Recent work in a number of species has emphasized the role of orbitofrontal cortex in value-based decision-making. However, discrepancies have arisen when comparing the findings from animal models to those from humans. In this review, the author examines several possibilities that might explain these discrepancies. Recent work has emphasized the role that orbitofrontal cortex (OFC) has in value-based decision-making. However, it is also clear that a number of discrepancies have arisen when comparing the findings from animal models to those from humans. Here, we examine several possibilities that might explain these discrepancies, including anatomical difference between species, the behavioral tasks used to probe decision-making and the methodologies used to assess neural function. Understanding how these differences affect the interpretation of experimental results will help us to better integrate future results from animal models. This will enable us to fully realize the benefits of using multiple approaches to understand OFC function.