Management and prognostic prediction of appendiceal mucinous adenocarcinoma with peritoneal metastasis: a single center study in China

• Published in: BMC cancer Vol. 20; no. 1; p. 280
• Main Authors: Ma, Ruiqing, Wang, Bing, Zhai, Xichao, Lu, Yiyan, Xu, Hongbin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.04.2020; BioMed Central; BMC
• Subjects: Abdomen; Adenocarcinoma; Adenocarcinoma, Mucinous - mortality; Adenocarcinoma, Mucinous - pathology; Adenocarcinoma, Mucinous - therapy; Adult; Aged; Analysis; Appendiceal mucinous adenocarcinoma; Appendiceal Neoplasms - mortality; Appendiceal Neoplasms - pathology; Appendiceal Neoplasms - therapy; Biomarkers, Tumor - metabolism; Cancer; Cancer metastasis; Chemotherapy; China; Combined Modality Therapy; Committees; Completeness of cytoreduction score; Cytoreduction Surgical Procedures - mortality; Disease Management; Female; Follow-Up Studies; Humans; Hyperthermia, Induced - mortality; Ki-67 Antigen - metabolism; Male; Medical prognosis; Metastases; Metastasis; Middle Aged; Multivariate analysis; Patients; Peritoneal Neoplasms - mortality; Peritoneal Neoplasms - secondary; Peritoneal Neoplasms - therapy; Peritoneum; Prognosis; Pseudomyxoma peritonei; Retrospective Studies; Surgery; Survival; Survival Rate; Tumors; Variables; China; Beijing China; Appendiceal mucinous adenocarcinoma; Prognosis; Completeness of cytoreduction score; Pseudomyxoma peritonei
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-020-06787-4

To investigate the clinical and pathological characteristics of appendiceal mucinous adenocarcinoma with peritoneal metastasis and analyze the prognostic factors. A retrospective analyses of clinicopathological features of 50 patients with appendiceal mucinous adenocarcinoma with peritoneal metastasis from January, 2013 to December, 2017 in Aerospace Central Hospital, Beijing, China. Survival data calculation and comparison were respectively performed with the Kaplan-Meier method and the log-rank test. The Cox proportional hazards regression method was used for multivariate survival analyses. Cytoreduction for appendiceal mucinous adenocarcinoma was conducted on 50 patients (24 males and 26 females), with a median age of 52.5 years at the time of surgery (range 31-71 years). The median overall survival (OS) time was 24 months, with 2-,3- and 5-year survival rates of 53, 24 and 8%, respectively. At the last follow-up in December 2018, 13 patients were still alive. Multivariate analysis revealed that patients who had low Ki-67 expression (less than 50%) and CCR (completeness of cytoreduction) 0/1/2 score had significantly better OS rate than their respective counterparts. Ki-67 expression statue and CCR score could be employed as the prognosis prediction in patients with appendiceal mucinous adenocarcinoma.