Prevalence of gastric cancer precursors in gastroscopy-screened adults by family history of gastric cancer and of cancers other than gastric

• Published in: BMC cancer Vol. 20; no. 1; p. 1110
• Main Authors: Wu, Rui, Yang, Cheng, Ji, Lin, Fan, Zhi-Ning, Tao, Yu-Wen, Zhan, Qiang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.11.2020; BioMed Central; BMC
• Subjects: Age; Biopsy; Cancer research; China - epidemiology; Complications and side effects; Cross-Sectional Studies; Dysplasia; Early Detection of Cancer - methods; Endoscopy; Familial diseases; Family history; Family medical history; Female; First-degree relative; Follow-Up Studies; Gastric cancer; Gastric Mucosa - pathology; Gastric precancerous lesions; Gastritis; Gastritis, Atrophic - diagnosis; Gastritis, Atrophic - epidemiology; Gastritis, Atrophic - genetics; Gastroscopy; Genetic Predisposition to Disease; Health aspects; Heredity; Humans; Intestine; Male; Metaplasia; Metaplasia - diagnosis; Metaplasia - epidemiology; Metaplasia - genetics; Middle Aged; Mortality; Pathology; Population; Precancerous Conditions - diagnosis; Precancerous Conditions - epidemiology; Precancerous Conditions - genetics; Prevalence; Prognosis; Risk Factors; Serology; Statistical analysis; Stomach cancer; Stomach Neoplasms - diagnosis; Stomach Neoplasms - epidemiology; Stomach Neoplasms - genetics; Tea; China; Japan; Pathology; Gastric precancerous lesions; First-degree relative; Family history
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-020-07612-8

People are at a high risk of gastric cancer if their first-degree relatives suffered from atrophic gastritis (AG), intestinal metaplasia (IM), intraepithelial neoplasia (IEN), dysplasia (DYS), or gastric cancer (GC). This study was performed to analyse the association between FDR-GC and GC precursors. A cross-sectional study was performed to screen the prevalence of GC precursors from November 2016 to September 2019. A total of 1329 participants with FDR-GC, 193 participants with a family history of non-gastric cancer in FDRs (FDR-nGC), and 860 participants without a family history of cancer in FDRs (FDR-nC) were recruited in this study. The logistic regression model was used in this study. The prevalence of normal, Non-AG, AG/IM, IEN/DYS, and GC was 31.91, 44.21, 13.81, 8.73, and 1.34%, respectively. The prevalence of IEN/DYS was higher in people with FDR-GC and FDR-nGC (FDR-GC: odds ratio (OR) = 1.655; 95%CI, 1.153-2.376; FDR-nGC: OR = 1.984; 95%CI, 1.122-3.506) than those with FDR-nC. The younger the age at which FDRs were diagnosed with GC, the more likely the participants were to develop AG/IM (P  = 0.019). The risk of precursors to GC was higher in participants whose FDR-GC was the mother than in those whose FDR-GC was the father or sibling (OR, non-AG: 1.312 vs. 1.007, 1.274; AG/IM: 1.430 vs. 1.296, 1.378; IEN/DYS: 1.988 vs. 1.573, 1.542). There was no statistically significant difference in non-AG (OR = 1.700; 95%CI, 0.940-3.074), AG/IM (OR = 1.291; 95%CI, 0.579-2.877), and IEN/DYS (OR = 1.265; 95%CI, 0.517-3.096) between participants with one or more FDR-GC. People with FDR-GC and FDR-nGC are at a high risk of IEN/DYS. When an FDR was diagnosed at a younger age, the risk of AG/IM was higher. The risk of GC precursors was higher in people whose FDR-GC was the mother.