Prognostic value of CAIX expression in oral squamous cell carcinoma: a systematic review and meta-analysis

• Published in: Journal of enzyme inhibition and medicinal chemistry Vol. 35; no. 1; pp. 1258 - 1266
• Main Authors: Lorenzo-Pouso, Alejandro I., Gallas-Torreira, Mercedes, Pérez-Sayáns, Mario, Chamorro-Petronacci, Cintia M., Alvarez-Calderon, Oscar, Takkouche, Bahi, Supuran, Claudiu T., García-García, Abel
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.01.2020; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Antigens, Neoplasm - metabolism; Biomarkers; Cancer; carbonic anhydrase; Carbonic Anhydrase IX - metabolism; Carbonic anhydrases; Carcinoma, Squamous Cell - metabolism; Decision making; Humans; Hypoxia; Medical prognosis; Meta-analysis; Metabolism; Mouth neoplasm; Odontology; Oral cancer; Oral squamous cell carcinoma; Preventive medicine; Prognosis; Proteins; Research Paper; Squamous cell carcinoma; Systematic review; Tumors; Mouth neoplasm; carbonic anhydrase; meta-analysis; hypoxia; prognosis
• ISSN: 1475-6366; 1475-6374; 1475-6374
• DOI: 10.1080/14756366.2020.1772250

Carbonic anhydrase IX (CAIX) is a hypoxia-related protein considered as a predictor for oral squamous cell carcinoma (OSCC) biological behaviour. Nevertheless, this prognostic value is still yet to be validated. We aim to quantify prognostic significance of CAIX overexpression in OSCC by meta-analysis. We performed searches in MEDLINE, EMBASE, SCOPUS, WOS, WHO'S databases, CPCI, and OATD from inception to August 2019. Overall survival (OS), disease-free survival (DFS), locoregional control (LC), and disease-specific survival (DSS) were considered as outcomes of interest. Overall 18 studies were included. CAIX overexpression was associated with worse OS (hazard ratio [HR] = 1.45 95% confidence interval [CI] 1.17-1.80) and DFS (HR = 1.98 95% CI 1.18-3.32). To the contrary, it was neither associated with LC (HR = 1.01 95% CI 0.50-2.02) nor with DSS (HR = 1.35 95% CI 0.78-2.33). Heterogeneity was negligible in all analyses except for DSS. Small studies effect was not significant for OS and DFS. This study shows that immunohistochemical CAIX assessment is a useful OSCC prognostic biomarker.