Urinary Metabolites of Valproic Acid in Epileptic Patients

The urinary excretion of valproic acid (VPA) and its metabolites (3-keto VPA, 3-OH VPA, and VPA-glucuronide) in 6 epileptic patients was studied using gas chromatography-mass spectrometry. The amount of VPA and 3-OH VPA excreted in the urine was low (0.1-0.5% of the dose of VPA and 0.6-1.5% of the d...

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Published inBiological & pharmaceutical bulletin Vol. 21; no. 3; pp. 304 - 307
Main Authors KATAYAMA, Hirokazu, WATANABE, Miki, YOSHITOMI, Hironori, YOSHIDA, Hisahiro, KIMOTO, Hiroo, KAMIYA, Akira, HAYASHI, Takashi, AKIMURA, Tatsuo
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 01.03.1998
Maruzen
Japan Science and Technology Agency
Subjects
Adolescent
Adult
Aged
Anticonvulsants - blood
Anticonvulsants - therapeutic use
Anticonvulsants - urine
Anticonvulsants. Antiepileptics. Antiparkinson agents
Biological and medical sciences
Epilepsy - blood
Epilepsy - drug therapy
Epilepsy - urine
epileptic patients
Female
Gas Chromatography-Mass Spectrometry
GC-MS
glucuronide
Humans
Male
Medical sciences
Middle Aged
Neuropharmacology
Pharmacology. Drug treatments
urinary excretion
valproic acid
Valproic Acid - blood
Valproic Acid - therapeutic use
Valproic Acid - urine
Human
Urine
Nervous system diseases
Epilepsy
Elimination
Anticonvulsant
Valproic acid
Metabolism
Cerebral disorder
Chemotherapy
Treatment
Central nervous system disease
Pharmacokinetics
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Summary:The urinary excretion of valproic acid (VPA) and its metabolites (3-keto VPA, 3-OH VPA, and VPA-glucuronide) in 6 epileptic patients was studied using gas chromatography-mass spectrometry. The amount of VPA and 3-OH VPA excreted in the urine was low (0.1-0.5% of the dose of VPA and 0.6-1.5% of the dose of 3-OH administered). The amount of 3-keto VPA and glucuronide (VPA-Glu) excreted was marked (5.8-26.2% and 13.1-88.7% of the dose of VPA administered, respectively). The urinary excretion of VPA and its metabolites by patients who have taken a normal amount of a VPA preparation was almost the same as that of healthy volunteers. Two epileptic patients who took a large amount of the VPA preparation showed a high excretion of VPA-Glu without an increase in their plasma VPA-Glu.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.21.304