Impact of early candidemia on the long-term outcome of allogeneic hematopoietic stem cell transplant in non-leukemic patients: an outcome analysis on behalf of IDWP–EBMT

• Published in: Bone marrow transplantation (Basingstoke) Vol. 56; no. 7; pp. 1563 - 1572
• Main Authors: Cesaro, Simone, Tridello, Gloria, Knelange, Nina Simone, Blijlevens, Nicole, Martin, Murray, Snowden, John A., Malladi, Ram, Ljungman, Per, Deconinck, Eric, Gedde-Dahl, Tobias, Byrne, Jennifer, Xhaard, Alienor, Chevallier, Patrice, Maertens, Johan, Zuckerman, Tsila, Lioure, Bruno, Petersen, Eefke, Cornelissen, Jan J., Arcese, William, Blaise, Didier, Milpied, Noel, Cahn, Jean Yves, Aljurf, Mahmoud, de Wreede, Liesbeth, Mauro, Margherita, de la Camara, Rafael, Averbuch, Diana, Mikulska, Malgorzata, Styczynski, Jan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2021; Nature Publishing Group
• Subjects: 692/308/2171; 692/699/255/1672; Bone marrow; Candidemia; Candidiasis; Care and treatment; Cell Biology; Hematology; Hematopoietic stem cells; Internal Medicine; Leukemia; Medicin och hälsovetenskap; Medicine; Medicine & Public Health; Mortality; Myeloproliferative disorders; Patient outcomes; Patients; Pediatrics; Public Health; Risk factors; Sepsis; Stem cell transplantation; Stem Cells; Transplantation; Europe
• ISSN: 0268-3369; 1476-5365; 1476-5365
• DOI: 10.1038/s41409-021-01212-1

We assessed the incidence and outcome of early candidemia after hematopoietic stem cell transplant (HSCT). The analysis included all first HSCTs performed from 2000 to 2015 in adult and pediatric patients with a non-leukemic disease and recorded in the EBMT registry. Overall survival (OS), non-relapse mortality (NRM), and relapse mortality (RM) were evaluated. Candidemia was diagnosed in 420 of 49,852 patients at a median time of 17 days post HSCT (range 0–100), the cumulative incidence being 0.85%. In 65.5% of episodes, candidemia occurred by day 30 after HSCT. The mortality rate by day 7 was 6.2%, whereas 100-day NRM was higher (HR 3.47, p  < 0.0001), and 100-day OS was lower (HR 3.22, p  < 0.0001) than that of patients without candidemia. After a median follow-up of 4.3 years, 5-year OS, NRM, and RM for patients with and without candidemia were 50.5% vs. 60.8%, p  < 0.0001, 28.2% vs.18.8%, p  < 0.0001, and 25.3% vs. 27.2%, p  = 0.4, respectively. In conclusion, in non-leukemic transplant patients, the occurrence of an early episode of candidemia is rare but it is still associated with a negative effect on the outcome.