From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications

• Published in: Blood Vol. 118; no. 24; pp. 6258 - 6268
• Main Authors: Hattangadi, Shilpa M., Wong, Piu, Zhang, Lingbo, Flygare, Johan, Lodish, Harvey F.
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 08.12.2011; Americain Society of Hematology; American Society of Hematology
• Subjects: Animals; Biological and medical sciences; Cell Proliferation; Chromatin - metabolism; Clinical Medicine; Epigenesis, Genetic; Erythrocytes - cytology; Erythrocytes - metabolism; Erythroid Precursor Cells - cytology; Erythroid Precursor Cells - metabolism; Erythropoiesis; Erythropoietin - metabolism; Hematologi; Hematologic and hematopoietic diseases; Hematology; Humans; Klinisk medicin; Medical and Health Sciences; Medical sciences; Medicin och hälsovetenskap; MicroRNAs - metabolism; Models, Biological; Red Cells, Iron, and Erythropoiesis; Review; Transcription, Genetic; Erythropoiesis; Modification; Blood cell; Chromatin; Hematology; RNA; Hematopoiesis; Stem cell; Red blood cell; Protein
• ISSN: 0006-4971; 1528-0020; 1528-0020
• DOI: 10.1182/blood-2011-07-356006

This article reviews the regulation of production of RBCs at several levels. We focus on the regulated expansion of burst-forming unit-erythroid erythroid progenitors by glucocorticoids and other factors that occur during chronic anemia, inflammation, and other conditions of stress. We also highlight the rapid production of RBCs by the coordinated regulation of terminal proliferation and differentiation of committed erythroid colony-forming unit-erythroid progenitors by external signals, such as erythropoietin and adhesion to a fibronectin matrix. We discuss the complex intracellular networks of coordinated gene regulation by transcription factors, chromatin modifiers, and miRNAs that regulate the different stages of erythropoiesis.