Serglycin proteoglycan in hematologic malignancies: a marker of acute myeloid leukemia

• Published in: Leukemia Vol. 21; no. 12; pp. 2406 - 2410
• Main Authors: NIEMANN, C. U, KJELDSEN, L, RALFKIAER, E, JENSEN, M. K, BORREGAARD, N
• Format: Journal Article
• Language: English
• Published: London Nature Publishing 01.12.2007; Nature Publishing Group
• Subjects: Acute lymphoblastic leukemia; Acute myeloid leukemia; Biological and medical sciences; Biomarkers, Tumor - analysis; Blood cancer; Blood Cells - chemistry; Bone Marrow Cells - chemistry; Cell Differentiation; Cytoplasmic Granules - chemistry; Cytotoxicity; Diagnosis; Diagnosis, Differential; Enzyme-linked immunosorbent assay; Genetic aspects; Granulocyte Precursor Cells - chemistry; Health aspects; Hematologic and hematopoietic diseases; Hematologic Neoplasms - diagnosis; Hematologic Neoplasms - metabolism; Humans; Immunohistochemistry; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism; Leukemia, Myeloid, Acute - diagnosis; Leukemia, Myeloid, Acute - metabolism; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative - metabolism; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Leukocytes (neutrophilic); Lymphatic leukemia; Lymphocytes; Lymphoma, Non-Hodgkin - metabolism; Markers; Mast cells; Medical sciences; Myeloid cells; Myeloproliferative diseases; Myeloproliferative disorders; Myeloproliferative Disorders - metabolism; Neoplasm Proteins - analysis; Neoplasm Proteins - blood; Peroxidase; Peroxidase - analysis; Philadelphia chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism; Predictive Value of Tests; Proteoglycans; Proteoglycans - analysis; Proteoglycans - blood; Vesicular Transport Proteins - analysis; Vesicular Transport Proteins - blood; Denmark; Human; Proteoglycan; AML; ALL; Acute myelogenous leukemia; Hematology; Biological marker; Malignant hemopathy; Differential diagnostic; Serglycin; serglycin proteoglycan; Lymphoproliferative syndrome; neutrophil elastase; granules; Diagnosis; Acute lymphocytic leukemia; Cancer
• ISSN: 0887-6924; 1476-5551
• DOI: 10.1038/sj.leu.2404975

Serglycin is the major cell-associated proteoglycan of hematopoietic cells. Previous work has demonstrated that serglycin may be involved in targeting some proteins to granules of cytotoxic lymphocytes, mast cells and neutrophils. We characterized the expression of serglycin in various hematologic malignancies by immunohistochemistry and ELISA. Serglycin expression was found to distinguish acute myeloid leukemia (AML) from acute lymphoblastic leukemia. In contrast to myeloperoxidase, serglycin was found to be a selective marker for immature myeloid cells, distinguishing AML from Philadelphia chromosome-negative chronic myeloproliferative disorders.