Recent advances of sonodynamic therapy in cancer treatment

Sonodynamic therapy （SDT） is an emerging approach that involves a combination of low-intensity ultrasound and specialized chemical agents known as sonosensitizers. Ultrasound can penetrate deeply into tissues and can be focused into a small region of a tumor to activate a sonosensitizer which offers...

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Published inCancer biology & medicine Vol. 13; no. 3; pp. 325 - 338
Main Authors Wan, Guo-Yun, Liu, Yang, Chen, Bo-Wei, Liu, Yuan-Yuan, Wang, Yin-Song, Zhang, Ning
Format Journal Article
LanguageEnglish
Published China Research Center of Basic Medical Science & School of Pharmacy, Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics Theranostics, Tianjin Medical University, Tianjin 300070, China 01.09.2016
Chinese Anti-Cancer Association
China Anti-Cancer Association
Subjects
cancer
reactive oxygen species
Review
Sonodynamic therapy
sonosensitizer
ultrasound
Reactive oxygen species
Ultrasound
Sonodynamic therapy
Sonosensitizer
Cancer
sonosensitizer
cancer
ultrasound
reactive oxygen species
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Summary:Sonodynamic therapy （SDT） is an emerging approach that involves a combination of low-intensity ultrasound and specialized chemical agents known as sonosensitizers. Ultrasound can penetrate deeply into tissues and can be focused into a small region of a tumor to activate a sonosensitizer which offers the possibility of non-invasively eradicating solid tumors in a site-directed manner. In this article, we critically reviewed the currently accepted mechanisms of sonodynamic action and summarized the classification of sonosensitizers. At the same time, the breath of evidence from SDT-based studies suggests that SDT is promising for cancer treatment.
Bibliography:Sonodynamic therapy （SDT） is an emerging approach that involves a combination of low-intensity ultrasound and specialized chemical agents known as sonosensitizers. Ultrasound can penetrate deeply into tissues and can be focused into a small region of a tumor to activate a sonosensitizer which offers the possibility of non-invasively eradicating solid tumors in a site-directed manner. In this article, we critically reviewed the currently accepted mechanisms of sonodynamic action and summarized the classification of sonosensitizers. At the same time, the breath of evidence from SDT-based studies suggests that SDT is promising for cancer treatment.
12-1431/R
Sonodynamic therapy; sonosensitizer; cancer; ultrasound; reactive oxygen species
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SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:2095-3941
2095-3941
DOI:10.20892/j.issn.2095-3941.2016.0068