Effects of low concentration fluoride released from fluoride-sustained-releasing composite resin on the bioactivity of Streptococcus mutans

This study aimed to determine the effects of the low concentration of fluoride sustained-released from the composite resin on properties of Streptococcus mutans (S. mutans). The proliferation, adhesion, biofilm formation, and lactic acid production of the bacterium were investigated after the treatm...

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Bibliographic Details
Published inDental Materials Journal Vol. 41; no. 2; pp. 309 - 316
Main Authors HAYASHI, Miki, MATSUURA, Ritaro, YAMAMOTO, Tetsuya
Format Journal Article
LanguageEnglish
Published Japan The Japanese Society for Dental Materials and Devices 25.03.2022
Japanese Society for Dental Materials and Devices
Japan Science and Technology Agency
Subjects
Acid production
Adenosine triphosphatase
Adhesion
Biofilm
Biofilms
Biological activity
Colorimetry
Composite materials
Composite resins
Composite Resins - pharmacology
Fluorides
Fluorides - metabolism
Fluorides - pharmacology
Glucosyltransferase
Glucosyltransferases
Hydrogen-Ion Concentration
Lactic acid
Phosphopyruvate hydratase
Releasing
Resins
Streptococcus infections
Streptococcus mutans
Biofilm
Glucosyltransferases
Composite resins
Phosphopyruvate hydratase
Streptococcus mutans
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Summary:This study aimed to determine the effects of the low concentration of fluoride sustained-released from the composite resin on properties of Streptococcus mutans (S. mutans). The proliferation, adhesion, biofilm formation, and lactic acid production of the bacterium were investigated after the treatment with fluoride from the composite resin. The activity and expression of ATPase, glucosyltransferase (GTF), and enolase were also determined by colorimetric assay and western blot analysis. Fluoride from the sustained-releasing composite resin significantly inhibited biofilm formation, adhesion, and acid production of S. mutans but did not influence the growth and ATPase activity of the bacterial strain. Fluoride-sustained-releasing composite resin inhibited adhesion, biofilm formation, and acid production of S. mutans through the suppression of GTF expression as well as the expression and activity of enolase. These resultls suggest the clinical significance of fluoride-sustained-releasing composite resin.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0287-4547
1881-1361
DOI:10.4012/dmj.2021-219