A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse

• Published in: Science (American Association for the Advancement of Science) Vol. 247; no. 4940; pp. 322 - 324
• Main Authors: Moser, Amy Rapaich, Pitot, Henry C., Dove, William F.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for the Advancement of Science 19.01.1990; American Association for the Advancement of Science; The American Association for the Advancement of Science
• Subjects: Adenoma; Adenoma - complications; Adenoma - genetics; Alleles; Anemia; Anemia - complications; Anemia - genetics; Animal tumors. Experimental tumors; Animals; Biological and medical sciences; Cancer; Cancer genetics; Digestive system; Digestive system cancer; Ethylnitrosourea; Experimental digestive system and abdominal tumors; Female; Gastrointestinal cancer; Genetic aspects; Genetic loci; Genetic mutation; Genetics; Hematocrit; House mouse; Intestinal neoplasms; Intestinal Neoplasms - complications; Intestinal Neoplasms - genetics; Intestinal Neoplasms - pathology; Male; Medical sciences; Mice; Mice as laboratory animals; Mice, Inbred AKR; Mice, Inbred C57BL; Mice, Mutant Strains; Mutagens; Mutation; Mutation (Biology); Neoplasia; Phenotypes; Physiological aspects; Tumors; Vertebrata; Mammalia; Multiple; Pathophysiology; Mouse; Animal; C-Onc gene; Rodentia; Gut; Digestive diseases; Tumor; Mutation
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.2296722

In a pedigree derived from a mouse treated with the mutagen ethylnitrosourea, a mutation has been identified that predisposes to spontaneous intestinal cancer. The mutant gene was found to be dominantly expressed and fully penetrant. Affected mice developed multiple adenomas throughout the entire intestinal tract at an early age.