Anti-Hepatitis B Virus and Cytotoxic Diterpenoids from Isodon lophanthoides var. gerardianus

• Published in: Chemical & pharmaceutical bulletin Vol. 59; no. 9; pp. 1102 - 1105
• Main Authors: Yang, Li-bin, Li, Lin, Huang, Sheng-xiong, Pu, Jian-xin, Zhao, Yong, Ma, Yun-bao, Chen, Ji-jun, Leng, Chun-hong, Tao, Zheng-ming, Sun, Han-dong
• Format: Journal Article
• Language: English
• Published: TOKYO The Pharmaceutical Society of Japan 01.09.2011; Pharmaceutical Soc Japan; Japan Science and Technology Agency
• Subjects: anti-hepatitis B virus; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - toxicity; Antiviral Agents - chemistry; Antiviral Agents - isolation & purification; Antiviral Agents - toxicity; Cell Line, Tumor; Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; Diterpenes - chemistry; Diterpenes - isolation & purification; Diterpenes - toxicity; diterpenoid; Drug Screening Assays, Antitumor; Hepatitis B; Hepatitis B e Antigens - drug effects; Hepatitis B Surface Antigens - drug effects; Hepatitis B virus - drug effects; Humans; Isodon - chemistry; Isodon lophanthoides var. gerardianus; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Pharmacology & Pharmacy; Physical Sciences; Plant Components, Aerial - chemistry; Science & Technology; TUMOR-CELL LINES; anti-hepatitis B virus; Isodon lophanthoides var. gerardianus; ASSAY; DIVERSE PANEL; diterpenoid; ABIETANE QUINONES; RABDOSIA-LOPHANTHOIDES
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.59.1102

Four new diterpenoides, isolophanthins A—D (1—4) together with seven known abietane diterpenoides (5—11), have been isolated from Isodon lophanthoides var. gerardianus. The new diterpenoides were elucidated by spectroscopic analysis. Some of them showed significant activities against HBsAg and HBeAg of hepatitis B virus in Hep G 2.2.15 cells, as well as the human tumor cell lines, HL-60, A-549, MOLT-4, and BEL-7402.