A randomized, double-blind, placebo-controlled crossover clinical trial to evaluate the anti-diabetic effects of Allium hookeri extract in the subjects with prediabetes

• Published in: BMC complementary and alternative medicine Vol. 20; no. 1; p. 211
• Main Authors: Park, Soo-Hyun, Bae, Ui-Jin, Choi, Eun-Kyung, Jung, Su-Jin, Lee, Sung-Hyen, Yang, Jae-Heon, Kim, You-Suk, Jeong, Do-Youn, Kim, Hyun-Ju, Park, Byung-Hyun, Chae, Soo-Wan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.07.2020; BioMed Central; BMC
• Subjects: Adult; Aged; Allium; Allium hookeri; animals; Antidiabetics; Antioxidants; Asia; Biomarkers - blood; Biomedical materials; Blood cholesterol; blood glucose; Blood Glucose - drug effects; Blood pressure; c-peptide; C-Peptide - blood; Cholesterol; Cholesterol tests; Clinical trials; complement; Creatinine; Cross-Over Studies; Diabetes; Diabetes mellitus; Diet; Dietary supplements; Double-Blind Method; Double-blind studies; fasting; Female; Functional foods & nutraceuticals; Glucose; Glucose tolerance; Glucose Tolerance Test; glucose tolerance tests; Glycated Hemoglobin A - metabolism; glycemic control; glycemic effect; glycohemoglobin; Glycosylated hemoglobin; Hemoglobin; Hemoglobin A1c; Herbal medicine; herbal medicines; High density lipoprotein; high density lipoprotein cholesterol; Humans; Incremental area under the curve; Inflammation; Insulin; Insulin - blood; Laboratories; Lifestyles; Low density lipoprotein; low density lipoprotein cholesterol; Low density lipoproteins; Male; Metabolism; Middle Aged; Nutrition research; Obesity; Oral glucose tolerance test; Osteoblasts; Oxidants; Oxidizing agents; placebos; Plant Extracts - therapeutic use; Plasma glucose; Prediabetes; Prediabetic state; Prediabetic State - drug therapy; Proteins; Republic of Korea; Statistical analysis; t-test; triacylglycerols; Triglycerides; Type 2 diabetes; Vegetables; Vital signs; Republic of Korea; South Korea; Japan; Germany; Asia; Oral glucose tolerance test; Prediabetes; Hemoglobin A1c; Allium hookeri; Incremental area under the curve; Plasma glucose
• ISSN: 2662-7671; 2662-7671; 1472-6882
• DOI: 10.1186/s12906-020-03005-3

Allium hookeri is widely consumed as a vegetable and herbal medicine in Asia. A. hookeri has been reported anti-inflammatory, anti-obesity, osteoblastic, anti-oxidant, and anti-diabetic effects in animal studies. We investigated the anti-diabetic effects of A. hookeri aqueous extract (AHE) in the Korean subjects. Prediabetic subjects (100 ≤ fasting plasma glucose (FPG) < 126 mg/dL) who met the inclusion criteria were recruited for this study. The enrolled subjects (n = 30) were randomly divided into either an AHE (n = 15, 486 mg/day) or placebo (n = 15) group. Outcomes were measurements of FPG, glycemic response to an oral glucose tolerance test (OGTT), insulin, C-peptide, hemoglobin A1c (HbA1c), total cholesterol, triglyceride, HDL-cholesterol, and LDL-cholesterol. The t-test was used to assess differences between the groups. A p-value < 0.05 was considered statistically significant. Eight weeks after AHE supplementation, HbA1c level was significantly decreased in the AHE group compared with the placebo group. No clinically significant changes in any safety parameter were observed. The findings suggest that AHE can be effective in reducing HbA1c, indicating it as an adjunctive tool for improving glycemic control. The study protocol was retrospectively registered at www.clinicaltrials.gov ( NCT03330366 , October 30, 2017).