Nuclear receptors: Decoding metabolic disease
Nuclear receptors (NR) are a superfamily of ligand-activated transcription factors that regulate development, reproduction, and metabolism of lipids, drugs and energy. The importance of this family of proteins in metabolic disease is exemplified by NR ligands used in the clinic or under exploratory...
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Published in | FEBS letters Vol. 582; no. 1; pp. 2 - 9 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier B.V
09.01.2008
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Subjects | |
Online Access | Get full text |
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Summary: | Nuclear receptors (NR) are a superfamily of ligand-activated transcription factors that regulate development, reproduction, and metabolism of lipids, drugs and energy. The importance of this family of proteins in metabolic disease is exemplified by NR ligands used in the clinic or under exploratory development for the treatment of diabetes mellitus, dyslipidemia, hypercholesterolemia, or other metabolic abnormalities. Genetic studies in humans and rodents support the notion that NRs control a wide variety of metabolic processes by regulating the expression of genes encoding key enzymes, transporters and other proteins involved in metabolic homeostasis. Current knowledge of complex NR metabolic networks is summarized here. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-3 ObjectType-Review-1 Current address: Genentech Inc.1 DNA Way, MS#37 South San Francisco, CA 94404 USA |
ISSN: | 0014-5793 1873-3468 |
DOI: | 10.1016/j.febslet.2007.11.016 |