Correction of DNA polymerase mistakes and 3'→5'-exonucleases of the rat liver

One of the levels of correcting the DNA polymerase mistakes is the 3'→5'-exonuclease «proofreading» activity being absent or non-effective for mammalian DNA polymerases. Cells are supposed to contain correcting 3'→5'-exonuclease non-bound covalently with DNA polymerases. Three 3&...

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Bibliographic Details
Published inBiopolimery i kletka Vol. 1; no. 5; pp. 253 - 258
Main Authors Belyakova, N. V., Kleiner, N. E., Kravetskaya, T. P., Legina, O. K., Timchenko, N. A., Krutyakov, V. M.
Format Journal Article
LanguageEnglish
Published Kiev Natsional'na Akademiya Nauk Ukrainy - National Academy of Sciences of Ukraine 20.09.1985
Subjects
Deoxyribonucleic acid
DNA
DNA polymerase
DNA-directed DNA polymerase
Exonuclease
Liver
Proofreading
Rodents
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Summary:One of the levels of correcting the DNA polymerase mistakes is the 3'→5'-exonuclease «proofreading» activity being absent or non-effective for mammalian DNA polymerases. Cells are supposed to contain correcting 3'→5'-exonuclease non-bound covalently with DNA polymerases. Three 3'→5'-exonucleases are isolated from the rat liver. To study their correcting ability both correct and incorrect [
ISSN:0233-7657
1993-6842
DOI:10.7124/bc.00018B