Overview of the coagulation system

Coagulation is a dynamic process and the understanding of the blood coagulation system has evolved over the recent years in anaesthetic practice. Although the traditional classification of the coagulation system into extrinsic and intrinsic pathway is still valid, the newer insights into coagulation...

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Bibliographic Details
Published inIndian journal of anaesthesia Vol. 58; no. 5; pp. 515 - 523
Main Authors Palta, Sanjeev, Saroa, Richa, Palta, Anshu
Format Journal Article
LanguageEnglish
Published India Medknow Publications and Media Pvt. Ltd 01.09.2014
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Wolters Kluwer Medknow Publications
Subjects
Anaesthesia
Anesthesia
Blood
Blood clots
Blood platelets
Blood transfusions
Coagulation
Coagulation system
Collagen
Embolisms
Endothelium
haemostasis
Hemophilia
Hypoxia
Medical research
Medicine, Experimental
Physiological aspects
Physiology
Proteins
Review
Surgery
Thrombosis
India
Anaesthesia
Coagulation system
haemostasis
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Summary:Coagulation is a dynamic process and the understanding of the blood coagulation system has evolved over the recent years in anaesthetic practice. Although the traditional classification of the coagulation system into extrinsic and intrinsic pathway is still valid, the newer insights into coagulation provide more authentic description of the same. Normal coagulation pathway represents a balance between the pro coagulant pathway that is responsible for clot formation and the mechanisms that inhibit the same beyond the injury site. Imbalance of the coagulation system may occur in the perioperative period or during critical illness, which may be secondary to numerous factors leading to a tendency of either thrombosis or bleeding. A systematic search of literature on PubMed with MeSH terms 'coagulation system, haemostasis and anaesthesia revealed twenty eight related clinical trials and review articles in last 10 years. Since the balance of the coagulation system may tilt towards bleeding and thrombosis in many situations, it is mandatory for the clinicians to understand physiologic basis of haemostasis in order to diagnose and manage the abnormalities of the coagulation process and to interpret the diagnostic tests done for the same.
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ISSN:0019-5049
0976-2817
DOI:10.4103/0019-5049.144643