Accounting for Bias in Estimates of the Rate of Polygenic Mutation

• Published in: Proceedings of the Royal Society. B, Biological sciences Vol. 253; no. 1338; pp. 291 - 296
• Main Authors: Keightley, Peter D., Mackay, Trudy Frances Charlene, Caballero, Armando
• Format: Journal Article
• Language: English
• Published: London The Royal Society 22.09.1993; Royal Society of London
• Subjects: Animals; Artificial selection; Biological and medical sciences; Drosophila; Drosophila melanogaster - genetics; Estimation bias; Fundamental and applied biological sciences. Psychology; Genetic mutation; Genetic variation; Genetics of eukaryotes. Biological and molecular evolution; Inbreeding; Invertebrata; Mathematics; Models, Genetic; Mutation; Phenotypic traits; Population genetics, reproduction patterns; Quantitative genetics; Quantitative traits; Viability; Hair; Genetic variability; Insecta; Estimation; Drosophilidae; Breeding line; Arthropoda; Methodological bias; Heritability; Mutation; Measurement method; Invertebrata; Drosophila melanogaster; Animal population; Diptera

Experimental data on the rate of response to artificial selection in initially inbred lines or the rate of divergence among inbred sublines can be used to estimate the rate of increase in variance of quantitative traits from new mutations. So far estimates have been based on the infinitesimal model...