Use of the Selective Oral Neuraminidase Inhibitor Oseltamivir to Prevent Influenza

Yearly immunization with inactivated vaccines is the main strategy for the prevention of influenza. 1 When substantial antigenic drift occurs after the formulation of a vaccine — as happened, for instance, during the 1997–1998 season, when the A/Sydney/5/97 variant of the H3N2 subtype circulated — l...

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Published inThe New England journal of medicine Vol. 341; no. 18; pp. 1336 - 1343
Main Authors Hayden, Frederick G, Atmar, Robert L, Schilling, Margo, Johnson, Casey, Poretz, Donald, Paar, David, Huson, Les, Ward, Penelope, Mills, Roger G
Format Journal Article
LanguageEnglish
Published Boston, MA Massachusetts Medical Society 28.10.1999
Subjects
Administration, Oral
Adolescent
Adult
Aged
Amines - adverse effects
Amines - therapeutic use
Biological and medical sciences
Clinical trials
Double-Blind Method
Drug Administration Schedule
Drug therapy
Enzyme Inhibitors - adverse effects
Enzyme Inhibitors - therapeutic use
Female
Humans
Influenza
Influenza A virus - classification
Influenza A virus - isolation & purification
Influenza B virus - isolation & purification
Influenza virus
Influenza, Human - prevention & control
Influenza, Human - virology
Male
Medical sciences
Middle Aged
Miscellaneous
Neuraminidase - antagonists & inhibitors
Oseltamivir
Pharmacology. Drug treatments
Preventive medicine
Human
Oral administration
Long term
Infection
Prevention
Randomization
Efficiency
Viral disease
Influenza
Neuraminic acid
Selection criterion
Inhibitor
Safety
Public health
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Summary:Yearly immunization with inactivated vaccines is the main strategy for the prevention of influenza. 1 When substantial antigenic drift occurs after the formulation of a vaccine — as happened, for instance, during the 1997–1998 season, when the A/Sydney/5/97 variant of the H3N2 subtype circulated — large outbreaks may occur, particularly among institutionalized patients at high risk for infection. 2 Influenza B virus may also cause such outbreaks. 3 , 4 The recent cluster of human cases of H5N1-subtype influenza in Hong Kong is another reminder of the continuing threat of pandemic influenza. 5 – 7 In the event of the rapid spread of a new influenzavirus, . . .
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM199910283411802