Role of the microbiome in occurrence, development and treatment of pancreatic cancer

Pancreatic cancer is one of the most lethal malignancies. Recent studies indicated that development of pancreatic cancer may be intimately connected with the microbiome. In this review, we discuss the mechanisms through which microbiomes affect the development of pancreatic cancer, including inflamm...

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Bibliographic Details
Published inMolecular cancer Vol. 18; no. 1; pp. 173 - 13
Main Authors Wang, Yicheng, Yang, Gang, You, Lei, Yang, Jinshou, Feng, Mengyu, Qiu, Jiangdong, Zhao, Fangyu, Liu, Yueze, Cao, Zhe, Zheng, Lianfang, Zhang, Taiping, Zhao, Yupei
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 01.12.2019
BioMed Central
BMC
Subjects
Bacteria
Blood groups
Cancer
Cancer therapies
Chemotherapy
Development and progression
Diagnosis
Diagnostic software
Disease
Drug therapy
Enzymes
Gastric cancer
Immunoglobulins
Immunomodulation
Immunotherapy
Inflammation
Medical prognosis
Medical research
Microbiomes
Microorganisms
Oncology, Experimental
Pancreatic cancer
Review
Studies
Chemotherapy
Diagnosis
Pancreatic cancer
Microbiomes
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Summary:Pancreatic cancer is one of the most lethal malignancies. Recent studies indicated that development of pancreatic cancer may be intimately connected with the microbiome. In this review, we discuss the mechanisms through which microbiomes affect the development of pancreatic cancer, including inflammation and immunomodulation. Potential therapeutic and diagnostic applications of microbiomes are also discussed. For example, microbiomes may serve as diagnostic markers for pancreatic cancer, and may also play an important role in determining the efficacies of treatments such as chemo- and immunotherapies. Future studies will provide additional insights into the various roles of microbiomes in pancreatic cancer.
ISSN:1476-4598
1476-4598
DOI:10.1186/s12943-019-1103-2