Successful Kidney Transplantation Ameliorates Arterial Stiffness in End-Stage Renal Disease Patients

• Published in: Transplantation proceedings Vol. 44; no. 3; pp. 684 - 686
• Main Authors: Hotta, K, Harada, H, Sasaki, H, Iwami, D, Fukuzawa, N, Morita, K, Seki, T, Togashi, M, Nonomura, K
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier Inc 01.04.2012; Elsevier
• Subjects: Adult; Arteries - physiopathology; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Compliance; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; Kidney Failure, Chronic - physiopathology; Kidney Failure, Chronic - surgery; Kidney Transplantation; Male; Medical sciences; Middle Aged; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the urinary system; Tissue, organ and graft immunology; Kidney disease; Human; Urinary system disease; Chronic renal failure; Cardiovascular disease; Patient; Homotransplantation; Kidney; Vascular disease; Medicine; Treatment; Urinary system; Surgery; Atherosclerosis; Renal failure; Graft; Stiffness; Kidney transplantation
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2011.11.016

Abstract Purpose Successful kidney transplantation (KTx) can ameliorate bodily damage caused by end-stage renal disease (ESRD). Arterial stiffness (AS) is one of the critical factors that shorten the survival of patients due to cardiovascular events. KTx may reduce AS as well; however, this has not been investigated well. We therefore conducted a retrospective study using noninvasive pulse wave velocity (PWV), which is a useful index of aortic damage. Patients and methods Fifty-eight consecutive kidney recipients (34 men, 24 women) were enrolled in this study. Mean age at transplantation was 40.5 ± 12.3 years and the dialysis period was 73.1 ± 95.8 months. The brachial-ankle PWV was measured preoperatively and 6 months postoperatively. First, we investigated the relationship between the PWV and the other parameters related to AS. Second, we studied the pre- to posttransplant change in PWV to evaluate the amelioration of AS after successful KTx. Results PWV showed significant positive correlations with age, systolic blood pressure (BP), diastolic BP, and abdominal aortic calcification index. After successful KTx, PWV significantly decreased ( P < .01). In addition, systolic and diastolic BP significantly decreased ( P < .01 and P < .05, respectively). Conclusion Successful KTx ameliorates AS in ESRD patients. This might explain the improved cardiovascular prognosis of ESRD patients who undergo KTx.