Genetic HLA Study of Kurds in Iraq, Iran and Tbilisi (Caucasus, Georgia): Relatedness and Medical Implications

• Published in: PloS one Vol. 12; no. 1; p. e0169929
• Main Authors: Arnaiz-Villena, Antonio, Palacio-Grüber, Jose, Muñiz, Ester, Campos, Cristina, Alonso-Rubio, Javier, Gomez-Casado, Eduardo, Salih, Shadallah Fareq, Martin-Villa, Manuel, Al-Qadi, Rawand
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.01.2017; Public Library of Science (PLoS)
• Subjects: Anthropology; Antigens; Biology and Life Sciences; Blood & organ donations; Chromosomes; Comparative analysis; Deoxyribonucleic acid; DNA; Drb1 protein; Earth Sciences; Epidemiology; Genes; Genetic aspects; Genetic distance; Georgia (Republic); Haplotypes; Histocompatibility antigen HLA; HLA antigens; HLA Antigens - genetics; Immunology; Iran; Iraq; Kurds; Laboratories; Medicine; Minority & ethnic groups; People and Places; Pharmacogenomics; Pharmacology; Phylogeny; Physiological aspects; Population; Populations; Side effects; Social Sciences; Transplantation; Iraq; Spain
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0169929

Kurds from Iraq (Dohuk and Erbil Area, North Iraq) have been analyzed for HLA genes. Their HLA genetic profile has been compared with that of other Kurd groups from Iran and Tbilisi (Georgia, Caucasus) and also Worldwide populations. A total of 7,746 HLA chromosomes have been used. Genetic distances, NJ dendrograms and correspondence analyses have been carried out. Haplotype HLA-B*52-DRB1*15 is present in all three analyzed Kurd populations. HLA-A*02-B*51-DRB1*11 is present in Iraq and Georgia Kurds. Haplotypes common to Iran and Iraq Kurds are HLA DRB1*11-DQB1*03, HLA DRB1*03-DQB1*02 and others in a lower frequency. Our HLA study conclusions are that Kurds most probably belong to an ancient Mediterranean / Middle East / Caucasian genetic substratum and that present results and those previously obtained by us in Kurds may be useful for Medicine in future Kurd transplantation programs, HLA Epidemiology (HLA linked diseases) and Pharmacogenomics (HLA-associated drug side effects) and also for Anthropology. It is discussed that one of the most ancient Kurd ancestor groups is in Hurrians (2,000 years BC).